| # | Players | Clubs | Nationality | GC | More |
|---|---|---|---|---|---|
| 1 | Manolo Reina | RCD Mallorca | Spain | 61 | |
| 2 | Diego Lopez | Espanyol | Spain | 60 | |
| 3 | Aitor Fernandez | Levante | Spain | 53 | |
| 4 | Marko Dmitrovic | Eibar | Serbia | 52 | |
| 5 | Joel Robles | Real Betis | Spain | 50 | |
| 6 | Rui Silva | Granada CF | Portugal | 43 | |
| 7 | Ruben Blanco | Celta Vigo | Spain | 43 | |
| 8 | Sergio Asenjo | Villarreal | Spain | 42 | |
| 9 | Jordi Masip | Real Valladolid | Spain | 40 | |
| 10 | Fernando Pacheco | CD Alaves | Spain | 39 | |
| 11 | Marc-Andre ter Stegen | Barcelona | Germany | 38 | |
| 12 | David Soria | Getafe | Spain | 38 | |
| 13 | Alejandro Remiro | Real Sociedad | Spain | 33 | |
| 14 | Ivan Cuellar | CD Leganes | Spain | 33 | |
| 15 | Unai Simon | Athletic Bilbao | Spain | 32 | |
| 16 | Tomas Vaclik | Sevilla | Czech Republic | 32 | |
| 17 | Jasper Cillessen | Valencia | Netherlands | 31 | |
| 18 | Jan Oblak | Atletico Madrid | Slovenia | 28 | |
| 19 | Sergio Herrera | Osasuna | Spain | 28 | |
| 20 | Ruben | Osasuna | Spain | 23 |
GC = Goals conceded