| A(D) | Clubs | VS | MD | |
|---|---|---|---|---|
| 24(189) | Vitesse Arnhem | Stade Rennes | 25-Nov-2021 | Match Details |
| 24(285) | Rapid Wien | Vitesse Arnhem | 17-Feb-2022 | Match Details |
| 24(352) | AS Roma | Bodo/Glimt | 21-Oct-2021 | Match Details |
| 24(12) | Tottenham Hotspur | Mura 05 | 30-Sep-2021 | Match Details |
| 24(59) | Sparta Prague | Partizan Belgrade | 24-Feb-2022 | Match Details |
| 24(80) | FC Copenhagen | Lincoln Red Imps | 25-Nov-2021 | Match Details |
| 24(171) | PSV Eindhoven | FC Copenhagen | 10-Mar-2022 | Match Details |
| 24(181) | Feyenoord | AS Roma | 25-May-2022 | Match Details |
| 25(211) | FC Basel | Qarabag FK | 16-Sep-2021 | Match Details |
| 25(263) | FC Midtylland | PAOK Salonika | 24-Feb-2022 | Match Details |
| 25(304) | AZ Alkmaar | Bodo/Glimt | 17-Mar-2022 | Match Details |
| 25(311) | Slavia Prague | Maccabi Haifa | 04-Nov-2021 | Match Details |
| 25(339) | Stade Rennes | Mura 05 | 04-Nov-2021 | Match Details |
| 25(22) | LASK Linz | Maccabi Tel Aviv | 25-Nov-2021 | Match Details |
| 25(83) | Flora Talinn | Partizan Belgrade | 25-Nov-2021 | Match Details |
| 25(120) | Omonia Nicosia | Qarabag FK | 25-Nov-2021 | Match Details |
| 25(129) | Qarabag FK | Omonia Nicosia | 25-Nov-2021 | Match Details |
| 25(178) | Bodo/Glimt | AS Roma | 04-Nov-2021 | Match Details |
| 26(271) | Leicester City | Stade Rennes | 17-Mar-2022 | Match Details |
| 26(277) | Celtic | Bodo/Glimt | 17-Feb-2022 | Match Details |
| 26(327) | FC Zorya Luhansk | Bodo/Glimt | 16-Sep-2021 | Match Details |
| 26(328) | Mura 05 | Tottenham Hotspur | 25-Nov-2021 | Match Details |
| 26(16) | Maccabi Tel Aviv | PSV Eindhoven | 17-Feb-2022 | Match Details |
| 26(52) | Olympique Marseille | Qarabag FK | 17-Feb-2022 | Match Details |
| 26(80) | HJK Helsinki | Maccabi Tel Aviv | 04-Nov-2021 | Match Details |
| 26(150) | Maccabi Haifa | Feyenoord | 14-Sep-2021 | Match Details |
| 27(310) | CSKA Sofia | AS Roma | 16-Sep-2021 | Match Details |
| 27(342) | Partizan Belgrade | Flora Talinn | 25-Nov-2021 | Match Details |
| 27(7) | Randers FC | Leicester City | 24-Feb-2022 | Match Details |
| 27(99) | Fenerbahce | Slavia Prague | 17-Feb-2022 | Match Details |
| 27(176) | 1. FC Union Berlin | Maccabi Haifa | 25-Nov-2021 | Match Details |
| 28(205) | PAOK Salonika | FC Copenhagen | 21-Oct-2021 | Match Details |
| 28(228) | FK Jablonec | AZ Alkmaar | 25-Nov-2021 | Match Details |
| 28(271) | KAA Gent | Partizan Belgrade | 21-Oct-2021 | Match Details |
| 28(36) | Kairat | Qarabag FK | 21-Oct-2021 | Match Details |
| 28(154) | Slovan Bratislava | Lincoln Red Imps | 21-Oct-2021 | Match Details |
| 29(55) | Lincoln Red Imps | Slovan Bratislava | 21-Oct-2021 | Match Details |
| 29(131) | Anorthosis Famagusta | KAA Gent | 25-Nov-2021 | Match Details |
| 29(146) | CFR Cluj | FK Jablonec | 16-Sep-2021 | Match Details |
| 30(228) | Alashkert FC | LASK Linz | 21-Oct-2021 | Match Details |
MD = Match date,
A(D) = Age(Days).