| Date | Result | OPP | FS | Home/Away |
|---|---|---|---|---|
| 19-Sep-2021 | lose |  Borussia Dortmund | 4-2 | away |
| 03-Oct-2021 | win |  1. FSV Mainz 05 | 1-2 | away |
| 30-Oct-2021 | lose |  Bayern Munich | 2-5 | home |
| 07-Nov-2021 | draw |  1. FC Koln | 2-2 | away |
| 28-Nov-2021 | lose |  Eintracht Frankfurt | 2-1 | away |
| 12-Dec-2021 | lose |  SpVgg Greuther Furth | 1-0 | away |
| 08-Jan-2022 | draw |  Bayer Leverkusen | 2-2 | away |
| 15-Jan-2022 | win |  TSG 1899 Hoffenheim | 2-1 | home |
| 05-Feb-2022 | lose |  FC Augsburg | 2-0 | away |
| 13-Feb-2022 | lose | Borussia Dortmund | 0-3 | home |
| 19-Feb-2022 | lose | Arminia Bielefeld | 1-0 | away |
| 05-Mar-2022 | lose |  VfL Wolfsburg | 1-0 | away |
| 19-Mar-2022 | lose | Bayern Munich | 4-0 | away |
| 23-Apr-2022 | win |  RB Leipzig | 1-2 | away |
| 29-Apr-2022 | draw | SpVgg Greuther Furth | 1-1 | home |
Overall ( 3 wins,3 draw,9 lost )
Home ( 1 wins,1 draw,2 lost )
Away ( 2 wins,2 draw,7 lost )
OPP = Opposition,
FS = Final score.