| Date | Result | OPP | FS | Home/Away |
|---|---|---|---|---|
| 28-Aug-2021 | draw |  Eintracht Frankfurt | 1-1 | home |
| 12-Sep-2021 | lose |  Borussia M'gladbach | 3-1 | away |
| 25-Sep-2021 | lose |  1. FC Union Berlin | 1-0 | away |
| 03-Oct-2021 | lose |  Bayer Leverkusen | 0-4 | home |
| 17-Oct-2021 | draw |  FC Augsburg | 1-1 | away |
| 23-Oct-2021 | lose |  Borussia Dortmund | 1-3 | home |
| 30-Oct-2021 | lose |  1. FSV Mainz 05 | 1-2 | home |
| 27-Nov-2021 | lose |  Bayern Munich | 1-0 | away |
| 04-Dec-2021 | draw |  1. FC Koln | 1-1 | home |
| 11-Dec-2021 | lose |  Hertha BSC | 2-0 | away |
| 08-Jan-2022 | draw |  SC Freiburg | 2-2 | away |
| 13-Feb-2022 | lose |  TSG 1899 Hoffenheim | 2-0 | away |
| 26-Feb-2022 | lose | Bayer Leverkusen | 3-0 | away |
| 04-Mar-2022 | lose | FC Augsburg | 0-1 | home |
| 13-Mar-2022 | lose | Borussia Dortmund | 1-0 | away |
| 19-Mar-2022 | lose | 1. FSV Mainz 05 | 4-0 | away |
| 02-Apr-2022 | draw | VfB Stuttgart | 1-1 | home |
| 09-Apr-2022 | lose |  VfL Wolfsburg | 4-0 | away |
| 17-Apr-2022 | lose | Bayern Munich | 0-3 | home |
| 23-Apr-2022 | lose | 1. FC Koln | 3-1 | away |
| 30-Apr-2022 | draw | Hertha BSC | 1-1 | home |
| 06-May-2022 | lose | VfL Bochum | 2-1 | away |
Overall ( 0 wins,6 draw,16 lost )
Home ( 0 wins,4 draw,5 lost )
Away ( 0 wins,2 draw,11 lost )
OPP = Opposition,
FS = Final score.