| Date | Result | OPP | FS | Home/Away |
|---|---|---|---|---|
| 14-Aug-2021 | lose |  TSG 1899 Hoffenheim | 0-4 | home |
| 28-Aug-2021 | lose |  Bayer Leverkusen | 1-4 | home |
| 26-Sep-2021 | lose |  SC Freiburg | 3-0 | away |
| 02-Oct-2021 | lose |  Borussia Dortmund | 2-1 | away |
| 22-Oct-2021 | lose |  1. FSV Mainz 05 | 4-1 | away |
| 31-Oct-2021 | win |  VfB Stuttgart | 4-1 | home |
| 06-Nov-2021 | lose |  VfL Wolfsburg | 1-0 | away |
| 27-Nov-2021 | draw |  Hertha BSC | 1-1 | away |
| 04-Dec-2021 | lose | VfL Bochum | 2-3 | home |
| 15-Dec-2021 | draw |  RB Leipzig | 1-1 | home |
| 16-Jan-2022 | draw |  Eintracht Frankfurt | 1-1 | home |
| 22-Jan-2022 | lose | Bayer Leverkusen | 5-1 | away |
| 12-Feb-2022 | lose |  Borussia M'gladbach | 3-2 | away |
| 19-Feb-2022 | lose | SC Freiburg | 1-2 | home |
| 27-Feb-2022 | draw | Borussia Dortmund | 1-1 | home |
| 09-Apr-2022 | lose |  Bayern Munich | 1-0 | away |
| 16-Apr-2022 | lose | Hertha BSC | 0-1 | home |
| 30-Apr-2022 | lose |  1. FC Koln | 1-4 | home |
| 08-May-2022 | lose | RB Leipzig | 4-0 | away |
Overall ( 1 wins,4 draw,14 lost )
Home ( 1 wins,3 draw,6 lost )
Away ( 0 wins,1 draw,8 lost )
OPP = Opposition,
FS = Final score.