| Date | Result | OPP | FS | Home/Away |
|---|---|---|---|---|
| 28-Aug-2021 | lose |  Bayern Munich | 5-0 | away |
| 17-Sep-2021 | win |  SpVgg Greuther Furth | 2-1 | home |
| 25-Sep-2021 | lose |  RB Leipzig | 6-0 | away |
| 02-Oct-2021 | lose |  SC Freiburg | 1-2 | home |
| 29-Oct-2021 | lose |  TSG 1899 Hoffenheim | 2-0 | away |
| 20-Nov-2021 | lose | 1. FC Union Berlin | 2-0 | away |
| 05-Dec-2021 | draw | VfB Stuttgart | 2-2 | away |
| 14-Dec-2021 | lose |  1. FSV Mainz 05 | 4-0 | away |
| 18-Dec-2021 | win |  Borussia Dortmund | 3-2 | home |
| 09-Jan-2022 | lose |  1. FC Koln | 1-3 | home |
| 23-Jan-2022 | lose | Bayern Munich | 1-4 | home |
| 12-Feb-2022 | lose | SpVgg Greuther Furth | 2-1 | away |
| 20-Feb-2022 | lose | RB Leipzig | 1-6 | home |
| 26-Feb-2022 | lose | SC Freiburg | 3-0 | away |
| 05-Mar-2022 | lose |  Eintracht Frankfurt | 1-4 | home |
| 12-Mar-2022 | lose |  Borussia M'gladbach | 2-0 | away |
| 02-Apr-2022 | lose |  Bayer Leverkusen | 2-1 | away |
| 09-Apr-2022 | lose | 1. FC Union Berlin | 1-4 | home |
| 07-May-2022 | lose | 1. FSV Mainz 05 | 1-2 | home |
Overall ( 2 wins,1 draw,16 lost )
Home ( 2 wins,0 draw,7 lost )
Away ( 0 wins,1 draw,9 lost )
OPP = Opposition,
FS = Final score.