| Date | Result | OPP | FS | Home/Away |
|---|---|---|---|---|
| 14-Aug-2021 | lose |  Real Madrid | 1-4 | home |
| 21-Aug-2021 | lose |  RCD Mallorca | 0-1 | home |
| 27-Aug-2021 | lose |  Valencia | 3-0 | away |
| 18-Sep-2021 | lose |  Osasuna | 0-2 | home |
| 22-Sep-2021 | lose |  Espanyol | 1-0 | away |
| 01-Oct-2021 | lose |  Athletic Bilbao | 1-0 | away |
| 18-Oct-2021 | lose |  Real Betis | 0-1 | home |
| 30-Oct-2021 | draw |  Barcelona | 1-1 | away |
| 06-Nov-2021 | win |  Levante | 2-1 | home |
| 27-Nov-2021 | lose |  Celta Vigo | 1-2 | home |
| 03-Dec-2021 | lose |  Granada CF | 2-1 | away |
| 11-Dec-2021 | draw |  Getafe | 1-1 | home |
| 18-Dec-2021 | lose |  Rayo Vallecano | 2-0 | away |
| 21-Dec-2021 | lose |  Villarreal | 5-2 | away |
| 02-Jan-2022 | draw |  Real Sociedad | 1-1 | home |
| 18-Jan-2022 | lose | Real Betis | 4-0 | away |
| 23-Jan-2022 | lose | Barcelona | 0-1 | home |
| 19-Feb-2022 | lose | Real Madrid | 3-0 | away |
| 13-Mar-2022 | lose | Real Sociedad | 1-0 | away |
| 02-Apr-2022 | lose |  Atletico Madrid | 4-1 | away |
| 10-Apr-2022 | lose | Osasuna | 1-0 | away |
| 19-Apr-2022 | lose | RCD Mallorca | 2-1 | away |
| 07-May-2022 | lose | Celta Vigo | 4-0 | away |
| 22-May-2022 | lose |  Cadiz CF | 0-1 | home |
Overall ( 1 wins,3 draw,20 lost )
Home ( 1 wins,2 draw,7 lost )
Away ( 0 wins,1 draw,13 lost )
OPP = Opposition,
FS = Final score.