| Date | Result | OPP | FS | Home/Away |
|---|---|---|---|---|
| 27-Aug-2021 | lose |  RCD Mallorca | 1-0 | away |
| 25-Sep-2021 | lose |  Sevilla | 2-0 | away |
| 23-Oct-2021 | draw |  Elche CF | 2-2 | away |
| 31-Oct-2021 | lose |  Getafe | 2-1 | away |
| 20-Nov-2021 | lose |  Barcelona | 1-0 | away |
| 05-Dec-2021 | lose |  Rayo Vallecano | 1-0 | away |
| 17-Dec-2021 | lose |  Celta Vigo | 3-1 | away |
| 31-Dec-2021 | win |  Valencia | 1-2 | away |
| 10-Jan-2022 | lose | Elche CF | 1-2 | home |
| 13-Feb-2022 | draw | Barcelona | 2-2 | home |
| 20-Feb-2022 | draw | Sevilla | 1-1 | home |
| 27-Feb-2022 | lose |  Villarreal | 5-1 | away |
| 04-Apr-2022 | lose |  Real Sociedad | 1-0 | away |
| 17-Apr-2022 | lose |  Atletico Madrid | 2-1 | away |
| 21-Apr-2022 | lose | Rayo Vallecano | 0-1 | home |
| 30-Apr-2022 | lose |  Real Madrid | 4-0 | away |
| 08-May-2022 | draw |  Osasuna | 1-1 | home |
| 11-May-2022 | lose |  CD Alaves | 2-1 | away |
| 14-May-2022 | draw | Valencia | 1-1 | home |
Overall ( 1 wins,5 draw,13 lost )
Home ( 0 wins,4 draw,2 lost )
Away ( 1 wins,1 draw,11 lost )
OPP = Opposition,
FS = Final score.