| Date | Result | OPP | FS | Home/Away |
|---|---|---|---|---|
| 22-Aug-2021 | draw |  Real Madrid | 3-3 | home |
| 28-Aug-2021 | lose |  Real Sociedad | 1-0 | away |
| 18-Sep-2021 | draw |  Elche CF | 1-1 | away |
| 21-Sep-2021 | lose |  Celta Vigo | 0-2 | home |
| 26-Sep-2021 | lose |  Barcelona | 3-0 | away |
| 02-Oct-2021 | lose |  RCD Mallorca | 1-0 | away |
| 24-Oct-2021 | lose |  Sevilla | 5-3 | away |
| 28-Oct-2021 | draw |  Atletico Madrid | 2-2 | home |
| 01-Nov-2021 | lose |  Granada CF | 0-3 | home |
| 11-Dec-2021 | lose |  Espanyol | 4-3 | away |
| 03-Jan-2022 | lose |  Villarreal | 5-0 | away |
| 22-Jan-2022 | lose |  Cadiz CF | 0-2 | home |
| 04-Feb-2022 | lose |  Getafe | 3-0 | away |
| 13-Feb-2022 | lose |  Real Betis | 2-4 | home |
| 21-Feb-2022 | draw | Celta Vigo | 1-1 | away |
| 07-Mar-2022 | lose |  Athletic Bilbao | 3-1 | away |
| 12-Mar-2022 | draw | Espanyol | 1-1 | home |
| 19-Mar-2022 | lose |  Osasuna | 3-1 | away |
| 21-Apr-2022 | lose | Sevilla | 2-3 | home |
| 30-Apr-2022 | draw |  Valencia | 1-1 | away |
| 12-May-2022 | lose | Real Madrid | 6-0 | away |
| 15-May-2022 | win |  CD Alaves | 3-1 | home |
| 20-May-2022 | win |  Rayo Vallecano | 2-4 | away |
Overall ( 2 wins,6 draw,15 lost )
Home ( 1 wins,3 draw,5 lost )
Away ( 1 wins,3 draw,10 lost )
OPP = Opposition,
FS = Final score.