| Date | Result | OPP | FS | Home/Away |
|---|---|---|---|---|
| 29-Aug-2021 | lose |  Rayo Vallecano | 4-0 | away |
| 13-Sep-2021 | lose |  Real Betis | 1-2 | home |
| 27-Sep-2021 | lose |  Celta Vigo | 1-0 | away |
| 22-Oct-2021 | draw |  Osasuna | 1-1 | away |
| 28-Oct-2021 | draw |  Getafe | 1-1 | home |
| 06-Nov-2021 | lose |  Espanyol | 2-0 | away |
| 21-Nov-2021 | lose |  Real Madrid | 1-4 | home |
| 26-Nov-2021 | draw |  Athletic Bilbao | 2-2 | away |
| 13-Dec-2021 | draw |  Cadiz CF | 1-1 | away |
| 22-Dec-2021 | win |  Atletico Madrid | 2-1 | home |
| 08-Jan-2022 | draw |  Barcelona | 1-1 | home |
| 20-Jan-2022 | lose | Getafe | 4-2 | away |
| 23-Jan-2022 | lose | Osasuna | 0-2 | home |
| 06-Feb-2022 | lose | Real Madrid | 1-0 | away |
| 13-Feb-2022 | lose |  Real Sociedad | 2-0 | away |
| 19-Feb-2022 | lose |  Villarreal | 1-4 | home |
| 05-Mar-2022 | lose |  Valencia | 3-1 | away |
| 12-Mar-2022 | lose |  Elche CF | 0-1 | home |
| 19-Mar-2022 | win |  CD Alaves | 2-3 | away |
| 03-Apr-2022 | draw | Rayo Vallecano | 2-2 | home |
| 17-Apr-2022 | lose |  Levante | 1-4 | home |
| 01-May-2022 | draw | Celta Vigo | 1-1 | home |
| 15-May-2022 | lose | Real Betis | 2-0 | away |
Overall ( 2 wins,7 draw,14 lost )
Home ( 1 wins,4 draw,6 lost )
Away ( 1 wins,3 draw,8 lost )
OPP = Opposition,
FS = Final score.