| Date | Result | OPP | FS | Home/Away |
|---|---|---|---|---|
| 14-Aug-2021 | win |  Eintracht Frankfurt | 5-2 | home |
| 27-Aug-2021 | win |  TSG 1899 Hoffenheim | 3-2 | home |
| 19-Sep-2021 | win |  1. FC Union Berlin | 4-2 | home |
| 02-Oct-2021 | win |  FC Augsburg | 2-1 | home |
| 16-Oct-2021 | win |  1. FSV Mainz 05 | 3-1 | home |
| 23-Oct-2021 | win | Arminia Bielefeld | 1-3 | away |
| 30-Oct-2021 | win |  1. FC Koln | 2-0 | home |
| 20-Nov-2021 | win | VfB Stuttgart | 2-1 | home |
| 04-Dec-2021 | lose |  Bayern Munich | 2-3 | home |
| 15-Dec-2021 | win | SpVgg Greuther Furth | 3-0 | home |
| 18-Dec-2021 | lose |  Hertha BSC | 3-2 | away |
| 14-Jan-2022 | win |  SC Freiburg | 5-1 | home |
| 22-Jan-2022 | win | TSG 1899 Hoffenheim | 2-3 | away |
| 13-Feb-2022 | win | 1. FC Union Berlin | 0-3 | away |
| 20-Feb-2022 | win |  Borussia M'gladbach | 6-0 | home |
| 27-Feb-2022 | draw | FC Augsburg | 1-1 | away |
| 13-Mar-2022 | win | Arminia Bielefeld | 1-0 | home |
| 16-Mar-2022 | win | 1. FSV Mainz 05 | 0-1 | away |
| 20-Mar-2022 | draw | 1. FC Koln | 1-1 | away |
| 08-Apr-2022 | win | VfB Stuttgart | 0-2 | away |
| 16-Apr-2022 | win |  VfL Wolfsburg | 6-1 | home |
| 07-May-2022 | win | SpVgg Greuther Furth | 1-3 | away |
Overall ( 18 wins,2 draw,2 lost )
Home ( 12 wins,0 draw,1 lost )
Away ( 6 wins,2 draw,1 lost )
OPP = Opposition,
FS = Final score.