| Date | Result | OPP | FS | Home/Away |
|---|---|---|---|---|
| 22-Aug-2021 | win |  1. FC Koln | 3-2 | home |
| 28-Aug-2021 | win |  Hertha BSC | 5-0 | home |
| 11-Sep-2021 | win |  RB Leipzig | 1-4 | away |
| 18-Sep-2021 | win |  VfL Bochum | 7-0 | home |
| 24-Sep-2021 | win | SpVgg Greuther Furth | 1-3 | away |
| 03-Oct-2021 | lose |  Eintracht Frankfurt | 1-2 | home |
| 17-Oct-2021 | win |  Bayer Leverkusen | 1-5 | away |
| 23-Oct-2021 | win |  TSG 1899 Hoffenheim | 4-0 | home |
| 30-Oct-2021 | win | 1. FC Union Berlin | 2-5 | away |
| 06-Nov-2021 | win |  SC Freiburg | 2-1 | home |
| 27-Nov-2021 | win | Arminia Bielefeld | 1-0 | home |
| 14-Dec-2021 | win | VfB Stuttgart | 0-5 | away |
| 17-Dec-2021 | win |  VfL Wolfsburg | 4-0 | home |
| 07-Jan-2022 | lose |  Borussia M'gladbach | 1-2 | home |
| 15-Jan-2022 | win | 1. FC Koln | 0-4 | away |
| 23-Jan-2022 | win | Hertha BSC | 1-4 | away |
| 05-Feb-2022 | win | RB Leipzig | 3-2 | home |
| 12-Feb-2022 | lose | VfL Bochum | 4-2 | away |
| 26-Feb-2022 | win | Eintracht Frankfurt | 0-1 | away |
| 05-Mar-2022 | draw | Bayer Leverkusen | 1-1 | home |
| 19-Mar-2022 | win | 1. FC Union Berlin | 4-0 | home |
| 02-Apr-2022 | win | SC Freiburg | 1-4 | away |
| 09-Apr-2022 | win |  FC Augsburg | 1-0 | home |
| 17-Apr-2022 | win | Arminia Bielefeld | 0-3 | away |
| 23-Apr-2022 | win |  Borussia Dortmund | 3-1 | home |
| 14-May-2022 | draw | VfL Wolfsburg | 2-2 | away |
Overall ( 21 wins,2 draw,3 lost )
Home ( 11 wins,1 draw,2 lost )
Away ( 10 wins,1 draw,1 lost )
OPP = Opposition,
FS = Final score.