| Date | Result | OPP | FS | Home/Away |
|---|---|---|---|---|
| 21-Aug-2021 | lose |  Internazionale | 4-0 | away |
| 29-Aug-2021 | lose |  Napoli | 1-2 | home |
| 12-Sep-2021 | win |  Cagliari | 2-3 | away |
| 18-Sep-2021 | lose |  Fiorentina | 1-2 | home |
| 21-Sep-2021 | draw |  Bologna | 2-2 | away |
| 25-Sep-2021 | draw |  Hellas Verona | 3-3 | home |
| 02-Oct-2021 | lose | Salernitana | 1-0 | away |
| 17-Oct-2021 | draw |  Sassuolo | 2-2 | home |
| 22-Oct-2021 | lose |  Torino | 3-2 | away |
| 26-Oct-2021 | draw | Spezia Calcio | 1-1 | away |
| 21-Nov-2021 | lose |  AS Roma | 0-2 | home |
| 01-Dec-2021 | lose |  AC Milan | 0-3 | home |
| 05-Dec-2021 | lose |  Juventus | 2-0 | away |
| 10-Dec-2021 | lose |  Sampdoria | 1-3 | home |
| 17-Dec-2021 | lose |  SS Lazio | 3-1 | away |
| 09-Jan-2022 | lose | Spezia Calcio | 0-1 | home |
| 17-Jan-2022 | lose | Fiorentina | 6-0 | away |
| 20-Feb-2022 | draw | Venezia | 1-1 | away |
| 04-Apr-2022 | lose | Hellas Verona | 1-0 | away |
| 10-Apr-2022 | lose | SS Lazio | 1-4 | home |
| 15-Apr-2022 | lose | AC Milan | 2-0 | away |
| 30-Apr-2022 | lose | Sampdoria | 1-0 | away |
| 06-May-2022 | win | Juventus | 2-1 | home |
| 15-May-2022 | lose | Napoli | 3-0 | away |
| 21-May-2022 | lose | Bologna | 0-1 | home |
Overall ( 2 wins,5 draw,18 lost )
Home ( 1 wins,2 draw,8 lost )
Away ( 1 wins,3 draw,10 lost )
OPP = Opposition,
FS = Final score.