| # | Players | Clubs | Nationality | GC | More |
|---|---|---|---|---|---|
| 1 | Fernando Pacheco | CD Alaves | Spain | 62 | |
| 2 | Luis Maximiano | Granada CF | Portugal | 57 | |
| 3 | Jeremias Ledesma | Cadiz CF | Argentina | 52 | |
| 4 | Diego Lopez | Espanyol | Spain | 51 | |
| 5 | Sergio Herrera | Osasuna | Spain | 48 | |
| 6 | Daniel Cardenas | Levante | Spain | 46 | |
| 7 | Jan Oblak | Atletico Madrid | Slovenia | 45 | |
| 8 | David Soria | Getafe | Spain | 43 | |
| 9 | Matias Dituro | Celta Vigo | Argentina | 43 | |
| 10 | Edgar Badia | Elche CF | Spain | 36 | |
| 11 | Stole Dimitrievski | Rayo Vallecano | North Macedonia | 35 | |
| 12 | Marc-Andre ter Stegen | Barcelona | Germany | 34 | |
| 13 | Unai Simon | Athletic Bilbao | Spain | 34 | |
| 14 | Alejandro Remiro | Real Sociedad | Spain | 32 | |
| 15 | Sergio Rico | RCD Mallorca | Spain | 31 | |
| 16 | Jasper Cillessen | Valencia | Netherlands | 30 | |
| 17 | Aitor Fernandez | Levante | Spain | 29 | |
| 18 | Geronimo Rulli | Villarreal | Argentina | 29 | |
| 19 | Thibaut Courtois | Real Madrid | Belgium | 29 | |
| 20 | Manolo Reina | RCD Mallorca | Spain | 27 |
GC = Goals conceded