| Date | Result | OPP | FS | Home/Away |
|---|---|---|---|---|
| 21-Aug-2021 | win |  Borussia M'gladbach | 4-0 | home |
| 28-Aug-2021 | win |  FC Augsburg | 1-4 | away |
| 11-Sep-2021 | lose |  Borussia Dortmund | 3-4 | home |
| 19-Sep-2021 | win |  VfB Stuttgart | 1-3 | away |
| 25-Sep-2021 | win |  1. FSV Mainz 05 | 1-0 | home |
| 03-Oct-2021 | win | Arminia Bielefeld | 0-4 | away |
| 24-Oct-2021 | draw |  1. FC Koln | 2-2 | away |
| 20-Nov-2021 | win | VfL Bochum | 1-0 | home |
| 28-Nov-2021 | win |  RB Leipzig | 1-3 | away |
| 04-Dec-2021 | win | SpVgg Greuther Furth | 7-1 | home |
| 12-Dec-2021 | lose |  Eintracht Frankfurt | 5-2 | away |
| 15-Dec-2021 | draw |  TSG 1899 Hoffenheim | 2-2 | home |
| 08-Jan-2022 | draw | 1. FC Union Berlin | 2-2 | home |
| 15-Jan-2022 | win | Borussia M'gladbach | 1-2 | away |
| 22-Jan-2022 | win | FC Augsburg | 5-1 | home |
| 06-Feb-2022 | win | Borussia Dortmund | 2-5 | away |
| 12-Feb-2022 | win | VfB Stuttgart | 4-2 | home |
| 18-Feb-2022 | lose | 1. FSV Mainz 05 | 3-2 | away |
| 26-Feb-2022 | win | Arminia Bielefeld | 3-0 | home |
| 20-Mar-2022 | win |  VfL Wolfsburg | 0-2 | away |
| 02-Apr-2022 | win |  Hertha BSC | 2-1 | home |
| 02-May-2022 | win | Eintracht Frankfurt | 2-0 | home |
| 14-May-2022 | win |  SC Freiburg | 2-1 | home |
Overall ( 17 wins,3 draw,3 lost )
Home ( 10 wins,2 draw,1 lost )
Away ( 7 wins,1 draw,2 lost )
OPP = Opposition,
FS = Final score.