| Date | Result | OPP | FS | Home/Away |
|---|---|---|---|---|
| 22-Aug-2021 | win |  FC Lorient | 3-1 | home |
| 29-Aug-2021 | lose |  Lille OSC | 2-1 | away |
| 19-Sep-2021 | draw |  Troyes AC | 1-1 | away |
| 25-Sep-2021 | lose |  Paris Saint-Germain | 2-0 | away |
| 24-Oct-2021 | lose |  AS Monaco | 3-1 | away |
| 20-Nov-2021 | lose |  Stade Rennes | 2-0 | away |
| 28-Nov-2021 | lose |  Olympique Lyonnais | 0-1 | home |
| 19-Jan-2022 | lose | Troyes AC | 0-1 | home |
| 12-Feb-2022 | lose | Lille OSC | 0-1 | home |
| 25-Feb-2022 | lose | Stade Rennes | 2-4 | home |
| 06-Mar-2022 | lose |  FC Nantes | 2-0 | away |
| 03-Apr-2022 | lose | Stade Brestois 29 | 1-2 | home |
| 10-Apr-2022 | lose |  Olympique Marseille | 2-0 | away |
| 20-Apr-2022 | lose | RC Lens | 2-0 | away |
| 23-Apr-2022 | lose | Olympique Lyonnais | 5-2 | away |
| 01-May-2022 | draw |  FC Metz | 2-2 | home |
| 08-May-2022 | lose | Clermont Foot | 2-1 | away |
| 14-May-2022 | lose | Paris Saint-Germain | 0-4 | home |
| 21-May-2022 | lose |  Angers SCO | 2-0 | away |
Overall ( 1 wins,2 draw,16 lost )
Home ( 1 wins,1 draw,6 lost )
Away ( 0 wins,1 draw,10 lost )
OPP = Opposition,
FS = Final score.