| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Jan Oblak | 38 | 38 | - | - | - | - |
Rodrigo de Paul | 37 | 24 | 13 | 13 | 15 | 3 |
Angel Correa | 36 | 21 | 15 | 15 | 16 | 12 |
Luis Suarez | 35 | 20 | 17 | 15 | 15 | 11 |
Yannick Carrasco | 34 | 28 | 6 | 6 | 14 | 6 |
Jorge Koke | 31 | 29 | 3 | 2 | 6 | 1 |
Marcos Llorente | 29 | 29 | - | - | 9 | - |
Renan Lodi | 29 | 13 | 23 | 16 | 11 | 2 |
Matheus Cunha | 29 | 8 | 22 | 21 | 8 | 6 |
Stefan Savic | 28 | 28 | 2 | - | 1 | - |
Geoffrey Kondogbia | 28 | 21 | 8 | 7 | 5 | 1 |
Antoine Griezmann | 26 | 21 | 6 | 5 | 16 | 3 |
Mario Hermoso | 26 | 21 | 12 | 5 | 7 | 2 |
Felipe | 26 | 15 | 19 | 11 | 1 | 2 |
Jose Maria Gimenez | 24 | 24 | 5 | - | 5 | 1 |
Joao Felix | 24 | 13 | 11 | 11 | 9 | 8 |
Thomas Lemar | 23 | 17 | 7 | 6 | 12 | 4 |
Sime Vrsaljko | 21 | 10 | 21 | 11 | 6 | 1 |
Hector Herrera | 21 | 8 | 22 | 13 | 4 | - |
Reinildo Mandava | 17 | 15 | 2 | 2 | 4 | - |
Kieran Trippier | 15 | 12 | 4 | 3 | 5 | - |
Javier Serrano | 5 | 1 | 19 | 4 | 1 | - |
Saul Niguez | 3 | 2 | 1 | 1 | - | - |
Giuliano Simeone | 1 | - | 14 | 1 | - | - |
Daniel Wass | 1 | - | 10 | 1 | - | - |
Carlos Martin | 1 | - | 10 | 1 | - | - |
Sergio Camello | - | - | 3 | - | - | - |
Antonio Gomis | - | - | 1 | - | - | - |
Ibrahima Camara | - | - | 4 | - | - | - |
Ivo Grbic | - | - | 1 | - | - | - |
Manu Lama | - | - | 1 | - | - | - |
Joan Rojas | - | - | 1 | - | - | - |
Benjamin Lecomte | - | - | 36 | - | - | - |
Nehuen Perez | - | - | 1 | - | - | - |
Pablo Barrios | - | - | 2 | - | - | - |
Marco Moreno | - | - | 2 | - | - | - |
Alberto Moreno | - | - | 1 | - | - | - |
Ivan Saponjic | - | - | 4 | - | - | - | 588 | 418 | 329 | 170 | 170 | 63 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .