| Date | Result | OPP | FS | Home/Away |
|---|---|---|---|---|
| 15-Aug-2021 | win |  Celta Vigo | 1-2 | away |
| 22-Aug-2021 | win |  Elche CF | 1-0 | home |
| 02-Oct-2021 | win |  Barcelona | 2-0 | home |
| 28-Oct-2021 | draw |  Levante | 2-2 | away |
| 31-Oct-2021 | win |  Real Betis | 3-0 | home |
| 07-Nov-2021 | draw |  Valencia | 3-3 | away |
| 20-Nov-2021 | win |  Osasuna | 1-0 | home |
| 28-Nov-2021 | win |  Cadiz CF | 1-4 | away |
| 04-Dec-2021 | lose |  RCD Mallorca | 1-2 | home |
| 22-Dec-2021 | lose |  Granada CF | 2-1 | away |
| 02-Jan-2022 | win |  Rayo Vallecano | 2-0 | home |
| 09-Jan-2022 | draw |  Villarreal | 2-2 | away |
| 06-Feb-2022 | lose | Barcelona | 4-2 | away |
| 12-Feb-2022 | win |  Getafe | 4-3 | home |
| 19-Feb-2022 | win | Osasuna | 0-3 | away |
| 26-Feb-2022 | win | Celta Vigo | 2-0 | home |
| 06-Mar-2022 | win | Real Betis | 1-3 | away |
| 11-Mar-2022 | win | Cadiz CF | 2-1 | home |
| 19-Mar-2022 | win | Rayo Vallecano | 0-1 | away |
| 02-Apr-2022 | win |  CD Alaves | 4-1 | home |
| 17-Apr-2022 | win |  Espanyol | 2-1 | home |
| 08-May-2022 | win |  Real Madrid | 1-0 | home |
| 11-May-2022 | win | Elche CF | 0-2 | away |
| 15-May-2022 | draw |  Sevilla | 1-1 | home |
| 22-May-2022 | win |  Real Sociedad | 1-2 | away |
Overall ( 18 wins,4 draw,3 lost )
Home ( 11 wins,1 draw,1 lost )
Away ( 7 wins,3 draw,2 lost )
OPP = Opposition,
FS = Final score.