| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Harry Maguire | 38 | 38 | - | - | - | 1 |
David De Gea | 38 | 38 | - | - | - | - |
Victor Lindelof | 35 | 35 | - | - | 2 | 1 |
Aaron Wan-Bissaka | 35 | 34 | 2 | 1 | 2 | - |
Daniel James | 33 | 26 | 11 | 7 | 11 | 3 |
Anthony Martial | 32 | 31 | 1 | 1 | 17 | 17 |
Marcus Rashford | 31 | 31 | - | - | 12 | 17 |
Mason Greenwood | 31 | 12 | 25 | 19 | 9 | 10 |
Fred | 29 | 23 | 11 | 6 | 2 | - |
Scott McTominay | 27 | 20 | 9 | 7 | 7 | 4 |
Andreas Pereira | 25 | 18 | 14 | 7 | 13 | 1 |
Luke Shaw | 24 | 20 | 5 | 4 | 5 | - |
Jesse Lingard | 22 | 9 | 17 | 13 | 9 | 1 |
Nemanja Matic | 21 | 18 | 9 | 3 | 5 | - |
Juan Mata | 19 | 8 | 30 | 11 | 6 | - |
Brandon Williams | 17 | 11 | 18 | 6 | 5 | 1 |
Paul Pogba | 16 | 13 | 3 | 3 | 3 | 1 |
Bruno Fernandes | 14 | 14 | - | - | 7 | 8 |
Ashley Young | 12 | 10 | 10 | 2 | 1 | - |
Odion Ighalo | 11 | - | 13 | 11 | - | - |
Axel Tuanzebe | 5 | 2 | 12 | 3 | - | - |
Eric Bailly | 4 | 1 | 13 | 3 | - | - |
Diogo Dalot | 4 | 1 | 7 | 3 | 1 | - |
Timothy Fosu-Mensah | 3 | 2 | 1 | 1 | 1 | - |
Marcos Rojo | 3 | 1 | 7 | 2 | - | - |
Tahith Chong | 3 | - | 6 | 3 | - | - |
Phil Jones | 2 | 2 | 10 | - | 1 | - |
Angel Gomes | 2 | - | 5 | 2 | - | - |
James Garner | 1 | - | 7 | 1 | - | - |
Lee Grant | - | - | 3 | - | - | - |
Sergio Romero | - | - | 35 | - | - | - | 537 | 418 | 284 | 119 | 119 | 65 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .