| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Giandomencio Mesto | 36 | 32 | 4 | 4 | 11 | 5 |
Guiseppe Sculli | 36 | 26 | 10 | 10 | 11 | 6 |
Omar Milanetto | 32 | 31 | 3 | 1 | 6 | 3 |
Rodrigo Palacio | 31 | 23 | 10 | 8 | 16 | 7 |
Marco Amelia | 30 | 30 | 5 | - | - | - |
Sokratis Papastathopoulos | 30 | 25 | 7 | 5 | 3 | - |
Domenico Criscito | 29 | 28 | 2 | 1 | 3 | 2 |
Emiliano Moretti | 29 | 28 | 3 | 1 | 5 | 1 |
Marco Rossi | 28 | 26 | 3 | 2 | 1 | 5 |
Salvatore Bocchetti | 28 | 25 | 6 | 3 | - | 1 |
Alberto Zapater | 28 | 19 | 16 | 9 | 5 | 3 |
Raffaele Palladino | 25 | 18 | 9 | 7 | 13 | 4 |
Giuseppe Biava | 20 | 18 | 2 | 2 | 1 | 1 |
Ivan Juric | 19 | 15 | 5 | 4 | 2 | - |
David Suazo | 16 | 11 | 6 | 5 | 9 | 3 |
Hernan Crespo | 16 | 6 | 14 | 10 | 4 | 5 |
Nenad Tomovic | 15 | 9 | 21 | 6 | 3 | - |
Sergio Floccari | 11 | 7 | 6 | 4 | 6 | 4 |
Robert Acquafresca | 10 | 8 | 2 | 2 | 3 | 2 |
Francesco Modesto | 10 | 8 | 7 | 2 | 4 | - |
Ivan Fatic | 10 | 3 | 18 | 7 | 1 | 1 |
Dario Dainelli | 9 | 8 | 1 | 1 | 2 | - |
Alessio Scarpi | 8 | 8 | 27 | - | - | - |
Houssine Kharja | 7 | 3 | 9 | 4 | 1 | 3 |
Andrea Esposito | 4 | 2 | 10 | 2 | - | - |
Richmond Boakye | 3 | - | 4 | 3 | 1 | 1 |
Bosko Jankovic | 3 | - | 3 | 3 | 1 | - |
Luciano Figueroa | 2 | 1 | 3 | 1 | 1 | - |
Stephan El Shaaraway | 2 | - | 7 | 2 | - | - |
Dejan Lazarevic | 2 | - | 9 | 2 | - | - |
Danijel Aleksic | 1 | - | 4 | 1 | - | - |
Isaac Cofie | 1 | - | 2 | 1 | - | - |
Danilo Russo | - | - | 4 | - | - | - |
Diego Fabian Polenta | - | - | 1 | - | - | - |
Antonio Ragusa | - | - | 2 | - | - | - |
Silvano Raggio Garibaldi | - | - | 4 | - | - | - |
Leonardo Terigi | - | - | 5 | - | - | - |
Alessio Grea | - | - | 1 | - | - | - |
Robert Gucher | - | - | 4 | - | - | - |
Alberto Frison | - | - | 1 | - | - | - | 531 | 418 | 260 | 113 | 113 | 57 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .