| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Tim Howard | 38 | 38 | - | - | - | - |
Phil Neville | 37 | 36 | 1 | 1 | 3 | - |
Joleon Lescott | 36 | 35 | 3 | 1 | - | 4 |
Philip Jagielka | 34 | 33 | 1 | 1 | - | - |
Leon Osman | 34 | 32 | 2 | 2 | 5 | 6 |
Leighton Baines | 31 | 26 | 12 | 5 | 2 | 1 |
Marouane Fellaini | 30 | 28 | 3 | 2 | 8 | 8 |
Tim Cahill | 30 | 28 | 2 | 2 | 9 | 8 |
Steven Pienaar | 28 | 27 | 1 | 1 | 4 | 2 |
Joseph Yobo | 27 | 26 | 4 | 1 | 1 | 1 |
Mikel Arteta | 26 | 26 | - | - | 4 | 5 |
Louis Saha | 24 | 10 | 14 | 14 | 9 | 6 |
Jack Rodwell | 19 | 9 | 26 | 10 | 2 | - |
Tony Hibbert | 17 | 16 | 7 | 1 | 4 | - |
Victor Anichebe | 17 | 5 | 13 | 12 | 4 | 1 |
Aiyegbeni Yakubu | 14 | 14 | - | - | 8 | 4 |
James Vaughan | 13 | 1 | 17 | 12 | 1 | - |
Jo | 12 | 11 | 2 | 1 | 8 | 5 |
Dan Gosling | 11 | 6 | 22 | 5 | 3 | 2 |
Segundo Castillo | 9 | 5 | 24 | 4 | 2 | - |
Lars Jacobsen | 5 | 4 | 11 | 1 | 3 | - |
Jose Baxter | 3 | 1 | 7 | 2 | 1 | - |
Nuno Valente | 2 | 1 | 8 | 1 | 1 | - |
Andy van der Meyde | 2 | - | 13 | 2 | - | - |
Lukasz Jutkiewicz | 1 | - | 12 | 1 | - | - |
John Kissock | - | - | 9 | - | - | - |
James Wallace | - | - | 10 | - | - | - |
Iain Turner | - | - | 3 | - | - | - |
Kieran Agard | - | - | 4 | - | - | - |
Carlo Nash | - | - | 35 | - | - | - | 500 | 418 | 266 | 82 | 82 | 53 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .