| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Joleon Lescott | 38 | 37 | 1 | 1 | - | 8 |
Phil Neville | 37 | 37 | - | - | 6 | 2 |
Tim Howard | 36 | 36 | - | - | - | - |
Lee Carsley | 34 | 33 | 4 | 1 | 5 | 1 |
Philip Jagielka | 34 | 27 | 11 | 7 | - | 1 |
Joseph Yobo | 30 | 29 | 2 | 1 | 2 | 1 |
Aiyegbeni Yakubu | 29 | 26 | 3 | 3 | 17 | 15 |
Andrew Johnson | 29 | 20 | 9 | 9 | 5 | 6 |
Mikel Arteta | 28 | 27 | 1 | 1 | 2 | 1 |
Leon Osman | 28 | 26 | 2 | 2 | 5 | 4 |
Steven Pienaar | 28 | 25 | 6 | 3 | 12 | 2 |
Victor Anichebe | 27 | 10 | 22 | 17 | 7 | 1 |
Tony Hibbert | 24 | 22 | 8 | 2 | 4 | - |
Leighton Baines | 22 | 13 | 12 | 9 | 2 | - |
Tim Cahill | 18 | 18 | - | - | 6 | 7 |
Manuel Fernandes | 12 | 9 | 4 | 3 | 5 | - |
James McFadden | 12 | 5 | 12 | 7 | 4 | 2 |
Nuno Valente | 9 | 8 | 14 | 1 | - | - |
Alan Stubbs | 8 | 7 | 5 | 1 | 2 | 1 |
Thomas Gravesen | 8 | 1 | 15 | 7 | 1 | - |
James Vaughan | 8 | - | 10 | 8 | - | 1 |
Stefan Wessels | 2 | 2 | 32 | - | - | - |
Jack Rodwell | 2 | - | 5 | 2 | - | - |
John Ruddy | - | - | 4 | - | - | - |
Andy van der Meyde | - | - | 4 | - | - | - |
Anderson De Silva | - | - | 1 | - | - | - |
Iain Turner | - | - | 2 | - | - | - |
Dan Gosling | - | - | 1 | - | - | - | 503 | 418 | 190 | 85 | 85 | 53 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .