| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 James Milner | 35 | 31 | 5 | 4 | 7 | 3 |
Obafemi Martins | 33 | 32 | 1 | 1 | 4 | 11 |
Nicky Butt | 31 | 27 | 7 | 4 | 5 | 1 |
Scott Parker | 29 | 28 | 1 | 1 | 3 | 3 |
Nolberto Solano | 28 | 25 | 4 | 3 | 10 | 2 |
Steven Taylor | 27 | 26 | 5 | 1 | - | 2 |
Antoine Sibierski | 26 | 14 | 14 | 12 | 6 | 3 |
Emre Belozoglu | 24 | 21 | 4 | 3 | 10 | 2 |
Stephen Carr | 23 | 23 | - | - | 1 | - |
Shay Given | 22 | 22 | - | - | 4 | - |
Kieron Dyer | 22 | 20 | 2 | 2 | 9 | 5 |
Damien Duff | 22 | 20 | 2 | 2 | 5 | 1 |
Charles N'Zogbia | 22 | 10 | 15 | 12 | 4 | - |
Peter Ramage | 21 | 20 | 5 | 1 | 2 | - |
Steve Harper | 18 | 15 | 14 | 3 | - | - |
Titus Bramble | 17 | 17 | 3 | - | 1 | - |
Craig Moore | 17 | 17 | - | - | 4 | - |
Celestine Babayaro | 12 | 12 | 3 | - | 1 | - |
Shola Ameobi | 12 | 9 | 3 | 3 | 6 | 3 |
Paul Huntington | 11 | 10 | 7 | 1 | 1 | 1 |
Oguchi Onyewu | 11 | 7 | 5 | 4 | - | - |
Giuseppe Rossi | 11 | 3 | 13 | 8 | - | - |
Matthew Pattison | 7 | 2 | 9 | 5 | - | - |
Albert Luque | 7 | - | 16 | 7 | - | - |
Andy Carroll | 4 | - | 12 | 4 | - | - |
Michael Owen | 3 | 3 | - | - | 1 | - |
David Edgar | 3 | 2 | 7 | 1 | - | 1 |
Alan O'Brien | 2 | 1 | 7 | 1 | - | - |
Pavel Srnicek | 2 | 1 | 20 | 1 | - | - |
James Troisi | - | - | 1 | - | - | - |
Tim Krul | - | - | 4 | - | - | - | 502 | 418 | 189 | 84 | 84 | 38 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .