| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Joseph Yobo | 38 | 38 | - | - | - | 2 |
Lee Carsley | 38 | 38 | - | - | 4 | 1 |
Joleon Lescott | 38 | 36 | 2 | 2 | 1 | 2 |
Tim Howard | 36 | 36 | - | - | - | - |
Phil Neville | 35 | 35 | - | - | 2 | 1 |
Mikel Arteta | 35 | 35 | - | - | 5 | 9 |
Leon Osman | 34 | 31 | 3 | 3 | 5 | 3 |
James Beattie | 33 | 15 | 23 | 18 | 11 | 2 |
Andrew Johnson | 32 | 32 | - | - | 7 | 11 |
Alan Stubbs | 23 | 23 | 3 | - | 2 | 2 |
James McFadden | 19 | 6 | 18 | 13 | 4 | 2 |
Victor Anichebe | 19 | 5 | 18 | 14 | 5 | 3 |
Tim Cahill | 18 | 17 | 1 | 1 | 4 | 5 |
Simon Davies | 15 | 13 | 5 | 2 | 4 | - |
Gary Naysmith | 15 | 10 | 14 | 5 | 4 | 1 |
Nuno Valente | 14 | 10 | 7 | 4 | 3 | - |
James Vaughan | 14 | 7 | 10 | 7 | 6 | 4 |
Tony Hibbert | 13 | 12 | 6 | 1 | 1 | - |
Manuel Fernandes | 9 | 8 | 2 | 1 | 4 | 2 |
Andy van der Meyde | 8 | 5 | 11 | 3 | 5 | - |
David Weir | 5 | 2 | 16 | 3 | 1 | - |
Kevin Kilbane | 2 | 2 | 1 | - | 1 | - |
Iain Turner | 1 | 1 | 6 | - | - | - |
Richard Wright | 1 | 1 | 30 | - | - | - |
Mark Hughes | 1 | - | 3 | 1 | - | - |
Anderson De Silva | 1 | - | 5 | 1 | - | - |
Bjarni Vidarsson | - | - | 1 | - | - | - |
Alessandro Pistone | - | - | 1 | - | - | - |
Patrick Boyle | - | - | 1 | - | - | - |
John Ruddy | - | - | 2 | - | - | - | 497 | 418 | 189 | 79 | 79 | 50 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .