| Date | Result | OPP | FS | Home/Away |
|---|---|---|---|---|
| 08-Aug-2021 | draw |  RC Lens | 1-1 | home |
| 15-Aug-2021 | draw | Stade Brestois 29 | 1-1 | away |
| 22-Aug-2021 | win |  FC Nantes | 1-0 | home |
| 22-Sep-2021 | win | Clermont Foot | 6-0 | home |
| 26-Sep-2021 | draw |  Girondins De Bordeaux | 1-1 | away |
| 03-Oct-2021 | win |  Paris Saint-Germain | 2-0 | home |
| 17-Oct-2021 | win |  FC Metz | 0-3 | away |
| 24-Oct-2021 | win | RC Strasbourg | 1-0 | home |
| 31-Oct-2021 | draw | Troyes AC | 2-2 | away |
| 07-Nov-2021 | win |  Olympique Lyonnais | 4-1 | home |
| 20-Nov-2021 | win |  Montpellier HSC | 2-0 | home |
| 28-Nov-2021 | win |  FC Lorient | 0-2 | away |
| 05-Dec-2021 | win |  AS Saint-Etienne | 0-5 | away |
| 22-Dec-2021 | lose |  AS Monaco | 2-1 | away |
| 16-Jan-2022 | win | Girondins De Bordeaux | 6-0 | home |
| 23-Jan-2022 | lose | Clermont Foot | 2-1 | away |
| 06-Feb-2022 | win | Stade Brestois 29 | 2-0 | home |
| 20-Feb-2022 | win | Troyes AC | 4-1 | home |
| 25-Feb-2022 | win | Montpellier HSC | 2-4 | away |
| 06-Mar-2022 | win |  Angers SCO | 2-0 | home |
| 13-Mar-2022 | win | Olympique Lyonnais | 2-4 | away |
| 20-Mar-2022 | win | FC Metz | 6-1 | home |
| 09-Apr-2022 | win | Stade Reims | 2-3 | away |
| 15-Apr-2022 | lose | AS Monaco | 2-3 | home |
| 24-Apr-2022 | win | FC Lorient | 5-0 | home |
| 30-Apr-2022 | win | AS Saint-Etienne | 2-0 | home |
| 11-May-2022 | lose | FC Nantes | 2-1 | away |
| 14-May-2022 | win |  Olympique Marseille | 2-0 | home |
Overall ( 20 wins,4 draw,4 lost )
Home ( 14 wins,1 draw,1 lost )
Away ( 6 wins,3 draw,3 lost )
OPP = Opposition,
FS = Final score.