| # | Players | Clubs | Nationality | GC | More |
|---|---|---|---|---|---|
| 1 | David Bingham | Los Angeles Galaxy | United States | 64 | |
| 2 | Tim Howard | Colorado Rapids | United States | 63 | |
| 3 | Andrew Tarbell | San Jose Earthquakes | United States | 61 | |
| 4 | Nick Rimando | Real Salt Lake | United States | 57 | |
| 5 | Joe Bendik | Orlando City | United States | 56 | |
| 6 | Evan Bush | Montreal Impact | United States | 55 | |
| 7 | Tyler Miller | Los Angeles FC | United States | 53 | |
| 8 | Bobby Shuttleworth | Minnesota United | United States | 51 | |
| 9 | Andre Blake | Philadelphia Union | Jamaica | 50 | |
| 10 | Richard Sanchez | Chicago Fire | Mexico | 48 | |
| 11 | Alex Bono | Toronto FC | United States | 46 | |
| 12 | Brad Guzan | Atlanta United | United States | 46 | |
| 13 | Stefan Marinovic | Vancouver Whitecaps | New Zealand | 45 | |
| 14 | Sean Johnson | New York City | United States | 43 | |
| 15 | Matt Turner | New England Revolution | United States | 43 | |
| 16 | Joe Willis | Houston Dynamo | United States | 42 | |
| 17 | Tim Melia | Sporting Kansas City | United States | 40 | |
| 18 | Zack Steffen | Columbus Crew | United States | 39 | |
| 19 | Stefan Frei | Seattle Sounders | Switzerland | 37 | |
| 20 | David Ousted | DC United | Denmark | 33 |
GC = Goals conceded