| # | Players | Clubs | Nationality | GC | More |
|---|---|---|---|---|---|
| 1 | Donovan Ricketts | Montreal Impact | Jamaica | 55 | |
| 2 | Dan Kennedy | Chivas USA | United States | 54 | |
| 3 | Matthew Pickens | Colorado Rapids | United States | 50 | |
| 4 | Troy Perkins | Portland Timbers | United States | 47 | |
| 5 | Milos Kocic | Toronto FC | Serbia | 47 | |
| 6 | Zac MacMath | Philadelphia Union | United States | 44 | |
| 7 | Andy Gruenebaum | Columbus Crew | United States | 43 | |
| 8 | Kevin Hartman | FC Dallas | United States | 42 | |
| 9 | Tally Hall | Houston Dynamo | United States | 40 | |
| 10 | Jon Busch | San Jose Earthquakes | United States | 40 | |
| 11 | Matt Reis | New England Revolution | United States | 39 | |
| 12 | Josh Saunders | Los Angeles Galaxy | United States | 38 | |
| 13 | Sean Johnson | Chicago Fire | United States | 36 | |
| 14 | Nick Rimando | Real Salt Lake | United States | 35 | |
| 15 | Joe Cannon | Vancouver Whitecaps | United States | 34 | |
| 16 | Bill Hamid | DC United | United States | 29 | |
| 17 | Jimmy Nielsen | Sporting Kansas City | Denmark | 28 | |
| 18 | Ryan Meara | New York Red Bulls | United States | 27 | |
| 19 | Bill Gaudette | Los Angeles Galaxy | United States | 21 | |
| 20 | Michael Gspurning | Seattle Sounders | Austria | 18 |
GC = Goals conceded