| # | Players | Clubs | Nationality | GC | More |
|---|---|---|---|---|---|
| 1 | Stefan Frei | Toronto FC | Switzerland | 52 | |
| 2 | Will Hesmer | Columbus Crew | United States | 46 | |
| 3 | Jon Busch | San Jose Earthquakes | United States | 44 | |
| 4 | Matt Reis | New England Revolution | United States | 43 | |
| 5 | Tally Hall | Houston Dynamo | United States | 42 | |
| 6 | Matthew Pickens | Colorado Rapids | United States | 41 | |
| 7 | Bill Hamid | DC United | United States | 41 | |
| 8 | Troy Perkins | Portland Timbers | United States | 40 | |
| 9 | Kasey Keller | Seattle Sounders | United States | 39 | |
| 10 | Sean Johnson | Chicago Fire | United States | 39 | |
| 11 | Nick Rimando | Real Salt Lake | United States | 37 | |
| 12 | Jimmy Nielsen | Sporting Kansas City | Denmark | 36 | |
| 13 | Dan Kennedy | Chivas USA | United States | 36 | |
| 14 | Kevin Hartman | FC Dallas | United States | 35 | |
| 15 | Joe Cannon | Vancouver Whitecaps | United States | 33 | |
| 16 | Faryd Mondragon | Philadelphia Union | Colombia | 29 | |
| 17 | Jay Nolly | Vancouver Whitecaps | United States | 21 | |
| 18 | Josh Saunders | Los Angeles Galaxy | United States | 19 | |
| 19 | Greg Sutton | New York Red Bulls | Canada | 17 | |
| 20 | Frank Rost | New York Red Bulls | Germany | 16 |
GC = Goals conceded