| # | Players | Clubs | Nationality | GC | More |
|---|---|---|---|---|---|
| 1 | Juan Pablo | Numancia | Spain | 62 | |
| 2 | Gorka Iraizoz | Athletic Bilbao | Spain | 61 | |
| 3 | Asier Riesgo | Recreativo | Spain | 56 | |
| 4 | Diego Alves | UD Almeria | Brazil | 53 | |
| 5 | Diego Lopez | Villarreal | Spain | 53 | |
| 6 | Iker Casillas | Real Madrid | Spain | 53 | |
| 7 | Leo Franco | Atletico Madrid | Argentina | 50 | |
| 8 | Carlos Kameni | Espanyol | Cameroon | 49 | |
| 9 | Daniel Aranzubia | Deportivo La Coruna | Spain | 47 | |
| 10 | Tono | Racing Santander | Spain | 44 | |
| 11 | Inaki Goitia | Malaga | Spain | 38 | |
| 12 | Andres Palop | Sevilla | Spain | 35 | |
| 13 | Victor Valdes | Barcelona | Spain | 34 | |
| 14 | Roberto | Osasuna | Spain | 29 | |
| 15 | Ivan Cuellar | Sporting Gijon | Spain | 29 | |
| 16 | Sergio Asenjo | Real Valladolid | Spain | 29 | |
| 17 | Justo Villar | Real Valladolid | Paraguay | 28 | |
| 18 | Inaki Lafuente | Sporting Gijon | Spain | 28 | |
| 19 | Renan Brito Soares | Valencia | Brazil | 27 | |
| 20 | Espinosa Casto | Real Betis | Spain | 25 |
GC = Goals conceded