| Group C | P | W | D | L | GF | GA | GD | points |
|---|---|---|---|---|---|---|---|---|
 Real Betis | 6 | 5 | 1 | 0 | 12 | 4 | 8 | 16 |
 AS Roma | 6 | 3 | 1 | 2 | 11 | 7 | 4 | 10 |
 Ludogorets Razgrad | 6 | 2 | 1 | 3 | 8 | 9 | -1 | 7 |
 HJK Helsinki | 6 | 0 | 1 | 5 | 2 | 13 | -11 | 1 |
Thursday 3 November 2022 | |||||||
| Real Betis | 3 | - | 0 | HJK Helsinki | 19:00 | STATS» | |
| AS Roma | 3 | - | 1 | Ludogorets Razgrad | 19:00 | STATS» | |
Thursday 27 October 2022 | |||||||
| HJK Helsinki | 1 | - | 2 | AS Roma | 19:00 | STATS» | |
| Ludogorets Razgrad | 0 | - | 1 | Real Betis | 16:45 | STATS» | |
Thursday 13 October 2022 | |||||||
| Ludogorets Razgrad | 2 | - | 0 | HJK Helsinki | 19:00 | STATS» | |
| Real Betis | 1 | - | 1 | AS Roma | 16:45 | STATS» | |
Thursday 6 October 2022 | |||||||
| AS Roma | 1 | - | 2 | Real Betis | 19:00 | STATS» | |
| HJK Helsinki | 1 | - | 1 | Ludogorets Razgrad | 16:45 | STATS» | |
Thursday 15 September 2022 | |||||||
| AS Roma | 3 | - | 0 | HJK Helsinki | 19:00 | STATS» | |
| Real Betis | 3 | - | 2 | Ludogorets Razgrad | 19:00 | STATS» | |
Thursday 8 September 2022 | |||||||
| HJK Helsinki | 0 | - | 2 | Real Betis | 16:45 | STATS» | |
| Ludogorets Razgrad | 2 | - | 1 | AS Roma | 16:45 | STATS» | |