| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Mikael Silvestre | 35 | 31 | 6 | 4 | 3 | - |
Paul Scholes | 35 | 30 | 6 | 5 | 5 | 8 |
Gary Neville | 34 | 31 | 4 | 3 | 2 | - |
Fabian Barthez | 32 | 32 | - | - | 2 | - |
Ruud van Nistelrooy | 32 | 29 | 6 | 3 | 9 | 23 |
Ole-Gunnar Solskjaer | 30 | 23 | 11 | 7 | 8 | 17 |
Laurent Blanc | 29 | 29 | - | - | 3 | 1 |
Roy Keane | 28 | 28 | - | - | 4 | 3 |
David Beckham | 28 | 23 | 6 | 5 | 4 | 11 |
Phil Neville | 28 | 21 | 14 | 7 | 2 | 2 |
Juan Sebastian Veron | 26 | 24 | 2 | 2 | 7 | 5 |
Nicky Butt | 25 | 20 | 10 | 5 | 5 | 1 |
Ryan Giggs | 25 | 18 | 9 | 7 | 7 | 7 |
Wes Brown | 17 | 15 | 3 | 2 | - | - |
Quinton Fortune | 14 | 8 | 6 | 6 | 3 | 1 |
Diego Forlan | 13 | 6 | 8 | 7 | 3 | - |
Denis Irwin | 12 | 10 | 13 | 2 | 8 | - |
Andrew Cole | 11 | 7 | 4 | 4 | 2 | 4 |
Ronny Johnsen | 10 | 9 | 2 | 1 | - | 1 |
Dwight Yorke | 10 | 4 | 11 | 6 | 3 | 1 |
John O'Shea | 9 | 4 | 13 | 5 | 1 | - |
Luke Chadwick | 8 | 5 | 6 | 3 | 4 | - |
Roy Carroll | 7 | 6 | 31 | 1 | - | - |
Michael Stewart | 3 | 2 | 3 | 1 | 2 | - |
David May | 2 | 2 | - | - | 1 | - |
Jaap Stam | 1 | 1 | - | - | - | - |
Raimonde van der Gouw | 1 | - | 7 | 1 | - | - |
Ronnie Wallwork | 1 | - | 7 | 1 | - | - |
Bojan Djordjic | - | - | 1 | - | - | - |
Mark Lynch | - | - | 1 | - | - | - | 506 | 418 | 190 | 88 | 88 | 85 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .