| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Adam Marusic | 36 | 33 | 4 | 3 | 5 | 2 |
Ciro Immobile | 35 | 34 | 1 | 1 | 17 | 20 |
Luis Alberto | 34 | 33 | 1 | 1 | 23 | 9 |
Sergej Milinkovic-Savic | 32 | 32 | 1 | - | 10 | 7 |
Franciesco Acerbi | 32 | 32 | - | - | 1 | - |
Manuel Lazzari | 32 | 30 | 2 | 2 | 9 | 2 |
Lucas Leiva | 32 | 30 | 2 | 2 | 28 | - |
Jean Daniel Akpa Akpro | 32 | 6 | 30 | 26 | 5 | - |
Stefan Radu | 31 | 30 | 1 | 1 | 11 | - |
Pepe Reina | 29 | 29 | 9 | - | - | - |
Joaquin Correa | 28 | 25 | 7 | 3 | 15 | 8 |
Vedat Muriqi | 26 | 7 | 23 | 19 | 5 | 1 |
Andreas Pereira | 26 | 3 | 28 | 23 | 2 | 1 |
Felipe Caicedo | 25 | 9 | 21 | 16 | 8 | 8 |
Patric | 24 | 18 | 15 | 6 | 9 | - |
Gonzalo Escalante | 24 | 4 | 25 | 20 | 5 | 1 |
Mohamed Fares | 21 | 12 | 15 | 9 | 9 | - |
Marco Parolo | 19 | 7 | 28 | 12 | 5 | - |
Danilo Cataldi | 19 | 4 | 29 | 15 | 4 | - |
Wesley Hoedt | 17 | 10 | 19 | 7 | 2 | - |
Senad Lulic | 16 | 8 | 13 | 8 | 7 | - |
Luiz Felipe | 14 | 10 | 6 | 4 | 6 | - |
Thomas Strakosha | 9 | 9 | 19 | - | - | - |
Mateo Musacchio | 4 | 2 | 13 | 2 | 1 | - |
Djavan Anderson | 3 | 1 | 15 | 2 | 1 | - |
Bastos | 2 | - | 2 | 2 | 1 | - |
Marco Bertini | 1 | - | 1 | 1 | - | - |
Denis Vavro | 1 | - | 2 | 1 | - | - |
Raul Moro | 1 | - | 6 | 1 | - | - |
Alessandro Murgia | 1 | - | 1 | 1 | - | - |
Nicolo Armini | 1 | - | 23 | 1 | - | - |
Damiano Franco | - | - | 5 | - | - | - |
Angelo Ndrecka | - | - | 1 | - | - | - |
Jordan Lukaku | - | - | 1 | - | - | - |
Sofian Kiyine | - | - | 2 | - | - | - |
Alessio Furlanetto | - | - | 8 | - | - | - |
Szymon Czyz | - | - | 4 | - | - | - |
Gabriel Valadares | - | - | 1 | - | - | - |
Gabriel Pereira | - | - | 4 | - | - | - |
Bobby Adekanye | - | - | 2 | - | - | - |
Marco Alia | - | - | 31 | - | - | - |
Mattia Novella | - | - | 2 | - | - | - |
Enzo Adeagbo | - | - | 3 | - | - | - | 607 | 418 | 426 | 189 | 189 | 59 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .