| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Wojciech Szczesny | 38 | 38 | - | - | - | - |
Federico Fazio | 37 | 35 | 3 | 2 | 3 | 2 |
Radja Nainggolan | 37 | 35 | 3 | 2 | 13 | 11 |
Edin Dzeko | 37 | 33 | 4 | 4 | 8 | 29 |
Kostas Manolas | 33 | 32 | 2 | 1 | 7 | 1 |
Kevin Strootman | 33 | 31 | 3 | 2 | 3 | 4 |
Diego Perotti | 32 | 20 | 14 | 12 | 13 | 8 |
Stephan El Shaaraway | 32 | 19 | 18 | 13 | 12 | 8 |
Mohamed Salah | 31 | 29 | 3 | 2 | 14 | 15 |
Daniele De Rossi | 31 | 27 | 7 | 4 | 9 | 4 |
Bruno Peres | 30 | 24 | 11 | 6 | 8 | 2 |
Leandro Paredes | 27 | 15 | 18 | 12 | 2 | 3 |
Antonio Rudiger | 26 | 25 | 1 | 1 | 2 | - |
Emerson | 25 | 23 | 12 | 2 | 4 | - |
Juan | 20 | 13 | 23 | 7 | 2 | - |
Francesco Totti | 18 | 1 | 29 | 17 | - | 2 |
Alessandro Florenzi | 9 | 8 | 1 | 1 | 3 | - |
Thomas Vermaelen | 9 | 4 | 21 | 5 | 1 | - |
Clement Grenier | 6 | 1 | 15 | 5 | 1 | - |
Mario Rui | 5 | 3 | 21 | 2 | - | - |
Juan Iturbe | 5 | - | 18 | 5 | - | - |
Gerson | 4 | 2 | 36 | 2 | 2 | - |
Andrea Romagnoli | - | - | 1 | - | - | - |
Moustapha Seck | - | - | 19 | - | - | - |
Riccardo Marchizza | - | - | 5 | - | - | - |
Emanuele Spinozzi | - | - | 2 | - | - | - |
Marco Tumminello | - | - | 3 | - | - | - |
Alisson | - | - | 38 | - | - | - |
Umar Sadiq | - | - | 1 | - | - | - |
Lorenzo Crisanto | - | - | 5 | - | - | - |
Bogdan Lobont | - | - | 28 | - | - | - |
Eros De Santis | - | - | 2 | - | - | - |
Stefano Greco | - | - | 1 | - | - | - |
Edoardo Soleri | - | - | 3 | - | - | - |
Luca Pellegrini | - | - | 2 | - | - | - |
Lorenzo Grossi | - | - | 2 | - | - | - |
Davide Frattesi | - | - | 1 | - | - | - |
Federico Ricci | - | - | 2 | - | - | - |
Abdullahi Nura | - | - | 1 | - | - | - | 525 | 418 | 379 | 107 | 107 | 89 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .