| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Kostas Manolas | 38 | 36 | 1 | 2 | 3 | 2 |
Radja Nainggolan | 35 | 33 | 2 | 2 | 5 | 6 |
Wojciech Szczesny | 34 | 34 | 1 | - | - | - |
Mohamed Salah | 34 | 32 | 2 | 2 | 18 | 14 |
Lucas Digne | 33 | 32 | 3 | 1 | 2 | 3 |
Alessandro Florenzi | 33 | 31 | 3 | 2 | 9 | 7 |
Miralem Pjanic | 33 | 30 | 4 | 3 | 5 | 10 |
Edin Dzeko | 31 | 21 | 13 | 10 | 5 | 8 |
Antonio Rudiger | 30 | 29 | 3 | 1 | - | 2 |
Daniele De Rossi | 24 | 23 | 7 | 1 | 6 | 1 |
Iago Falque | 22 | 13 | 20 | 9 | 10 | 2 |
Seydou Keita | 20 | 16 | 12 | 4 | 4 | 1 |
Stephan El Shaaraway | 16 | 15 | 2 | 1 | 12 | 8 |
William Vainqueur | 16 | 4 | 29 | 12 | 2 | - |
Diego Perotti | 15 | 14 | 1 | 1 | 2 | 3 |
Gervinho | 14 | 13 | 3 | 1 | 6 | 6 |
Maicon | 14 | 12 | 20 | 2 | 7 | 1 |
Francesco Totti | 13 | 2 | 21 | 11 | 3 | 5 |
Juan Iturbe | 12 | 3 | 13 | 9 | 3 | 1 |
Vasilis Torosidis | 11 | 6 | 23 | 5 | 1 | - |
Ervin Zukanovic | 9 | 6 | 11 | 3 | 3 | - |
Emerson | 8 | 1 | 34 | 7 | 1 | 1 |
Umar Sadiq | 6 | 2 | 22 | 4 | 2 | 2 |
Norbert Gyomber | 6 | - | 24 | 6 | - | - |
Leandro Castan | 5 | 4 | 32 | 1 | 1 | - |
Kevin Strootman | 5 | 2 | 11 | 3 | 1 | - |
Morgan De Sanctis | 4 | 4 | 33 | - | - | - |
Salih Ucan | 3 | - | 27 | 3 | - | - |
Victor Ibarbo | 2 | - | 2 | 2 | - | - |
Adem Ljajic | 1 | - | 2 | 1 | - | - |
Lorenzo Di Livio | 1 | - | 4 | 1 | - | - |
Marco Tumminello | 1 | - | 3 | 1 | - | - |
Christian D'Urso | - | - | 4 | - | - | - |
Pepin | - | - | 5 | - | - | - |
Bogdan Lobont | - | - | 13 | - | - | - |
Eros De Santis | - | - | 2 | - | - | - |
Leandro Paredes | - | - | 2 | - | - | - |
Riccardo Marchizza | - | - | 1 | - | - | - |
Abdullahi Nura | - | - | 5 | - | - | - |
Edoardo Soleri | - | - | 1 | - | - | - |
Ezequiel Ponce | - | - | 9 | - | - | - | 529 | 418 | 430 | 111 | 111 | 83 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .