| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Marek Hamsik | 38 | 38 | - | - | 18 | 6 |
Jose Callejon | 38 | 35 | 3 | 3 | 19 | 7 |
Elseid Hysaj | 37 | 37 | - | - | 2 | - |
Pepe Reina | 37 | 37 | 1 | - | - | - |
Raul Albiol | 36 | 36 | - | - | - | 1 |
Gonzalo Higuain | 35 | 35 | - | - | 14 | 36 |
Jorginho | 35 | 32 | 4 | 3 | 3 | - |
Allan | 35 | 32 | 4 | 3 | 9 | 3 |
Faouzi Ghoulam | 34 | 32 | 5 | 2 | 2 | - |
Lorenzo Insigne | 34 | 31 | 4 | 3 | 26 | 12 |
Kalidou Koulibaly | 33 | 32 | 4 | 1 | 1 | - |
Dries Mertens | 33 | 6 | 29 | 27 | 5 | 5 |
David Lopez | 25 | 6 | 32 | 19 | 3 | 1 |
Manolo Gabbiadini | 23 | 4 | 30 | 19 | 3 | 5 |
Omar El Kaddouri | 20 | - | 37 | 20 | - | 1 |
Vlad Chiriches | 8 | 8 | 27 | - | 1 | 1 |
Christian Maggio | 8 | 4 | 34 | 4 | - | - |
Mirko Valdifiori | 6 | 6 | 32 | - | 3 | - |
Ivan Strinic | 5 | 3 | 33 | 2 | 1 | - |
Nathaniel Chalobah | 5 | - | 31 | 5 | - | - |
Roberto Insigne | 3 | 3 | - | - | 2 | - |
Gabriel | 1 | 1 | 37 | - | - | - |
Vasco Regini | 1 | - | 16 | 1 | - | - |
Jacopo Dezi | - | - | 7 | - | - | - |
Rafael Cabral | - | - | 38 | - | - | - |
Henrique | - | - | 17 | - | - | - |
Sebastiano Luperto | - | - | 14 | - | - | - |
Alberto Grassi | - | - | 10 | - | - | - | 530 | 418 | 449 | 112 | 112 | 78 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .