| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Rodrigo Palacio | 37 | 36 | 1 | 1 | 4 | 17 |
Samir Handanovic | 36 | 36 | - | - | 1 | - |
Yuto Nagatomo | 34 | 32 | 4 | 2 | 3 | 5 |
Esteban Cambiasso | 32 | 32 | 3 | - | 8 | 4 |
Fredy Guarin | 32 | 26 | 9 | 6 | 12 | 4 |
Mateo Kovacic | 32 | 14 | 23 | 18 | 6 | - |
Jonathan | 31 | 31 | 2 | - | 11 | 3 |
Rolando | 29 | 28 | 9 | 1 | - | 4 |
Ricardo Alvarez | 29 | 25 | 5 | 4 | 9 | 4 |
Juan | 27 | 27 | 1 | - | 3 | - |
Saphir Taider | 26 | 13 | 24 | 13 | 10 | 1 |
Andrea Ranocchia | 24 | 23 | 13 | 1 | 3 | 1 |
Hugo Campagnaro | 21 | 20 | 9 | 1 | 6 | - |
Mauro Icardi | 21 | 12 | 19 | 9 | 6 | 9 |
Diego Milito | 17 | 6 | 20 | 11 | 3 | 2 |
Zdravko Kuzmanovic | 15 | 11 | 23 | 4 | 8 | - |
Walter Samuel | 14 | 13 | 17 | 1 | 2 | 2 |
Hernanes | 14 | 13 | 2 | 1 | 5 | 2 |
Javier Zanetti | 12 | 4 | 24 | 8 | 2 | - |
Danilo D'Ambrosio | 11 | 8 | 7 | 3 | 5 | - |
Ruben Botta | 9 | 1 | 19 | 8 | 1 | - |
Ishak Belfodil | 8 | 1 | 15 | 7 | 1 | - |
Alvaro Pereira | 5 | 2 | 15 | 3 | 1 | - |
Juan Carrizo | 4 | 2 | 33 | 2 | - | - |
Marco Andreolli | 3 | 2 | 35 | 1 | - | 1 |
Wallace | 3 | - | 18 | 3 | - | - |
Gaby Mudingayi | 1 | - | 18 | 1 | - | - |
Federico Bonazzoli | 1 | - | 1 | 1 | - | - |
Patrick Olsen | - | - | 10 | - | - | - |
George Puscas | - | - | 4 | - | - | - |
Isaac Donkor | - | - | 5 | - | - | - |
Luca Castellazzi | - | - | 36 | - | - | - |
Marko Livaja | - | - | 1 | - | - | - | 528 | 418 | 425 | 110 | 110 | 59 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .