| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Cristian Ledesma | 36 | 35 | 1 | 1 | 10 | 1 |
Antonio Candreva | 35 | 32 | 3 | 3 | 14 | 6 |
Federico Marchetti | 34 | 34 | - | - | - | - |
Hernanes | 34 | 30 | 4 | 4 | 12 | 11 |
Alvaro Gonzalez | 34 | 29 | 6 | 5 | 12 | 1 |
Senad Lulic | 33 | 29 | 5 | 4 | 4 | 1 |
Giuseppe Biava | 31 | 30 | 5 | 1 | 3 | 1 |
Miroslav Klose | 29 | 26 | 3 | 3 | 11 | 15 |
Andre Dias | 27 | 25 | 4 | 2 | 2 | - |
Stefano Mauri | 26 | 23 | 8 | 3 | 10 | 3 |
Abdoulay Konko | 25 | 25 | 2 | - | 4 | 1 |
Lorik Cana | 24 | 13 | 20 | 11 | - | - |
Stefan Radu | 23 | 22 | 5 | 1 | 5 | 1 |
Sergio Floccari | 22 | 11 | 22 | 11 | 5 | 5 |
Libor Kozak | 19 | 5 | 30 | 14 | 2 | - |
Michael Ciani | 18 | 13 | 21 | 5 | 1 | - |
Ogenyi Onazi | 15 | 8 | 22 | 7 | 2 | 1 |
Honorato Ederson | 15 | 4 | 14 | 11 | 4 | 1 |
Luis Pedro Cavanda | 14 | 8 | 13 | 6 | 2 | - |
Bruno Pereirinha | 8 | 3 | 7 | 5 | 1 | - |
Christian Brocchi | 8 | 2 | 10 | 6 | 3 | - |
Louis Saha | 6 | 1 | 13 | 5 | 1 | - |
Albano Bizzarri | 4 | 4 | 34 | - | - | - |
Lionel Scaloni | 4 | 1 | 19 | 3 | 1 | - |
Tommaso Rocchi | 3 | 2 | 12 | 1 | 2 | - |
Marius Stankevicius | 3 | 2 | 14 | 1 | 1 | - |
Mauro Zarate | 1 | 1 | 10 | - | 1 | - |
Luca Crecco | 1 | - | 3 | 1 | - | - |
Alessandro Berardi | - | - | 1 | - | - | - |
Riccardo Serpieri | - | - | 1 | - | - | - |
Guido Guerrieri | - | - | 1 | - | - | - |
Juan Carrizo | - | - | 15 | - | - | - |
Luciano Zauri | - | - | 7 | - | - | - |
Modibo Diakite | - | - | 6 | - | 1 | - |
Thomas Strakosha | - | - | 10 | - | - | - |
Antonio Rozzi | - | - | 19 | - | - | - |
Tiziano Scarfagna | - | - | 5 | - | - | - |
Danilo Cataldi | - | - | 2 | - | - | - | 532 | 418 | 377 | 114 | 114 | 48 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .