| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Morgan De Sanctis | 37 | 37 | 1 | - | - | - |
Marek Hamsik | 37 | 30 | 7 | 7 | 12 | 9 |
Gokhan Inler | 36 | 29 | 8 | 7 | 8 | - |
Edinson Cavani | 35 | 32 | 3 | 3 | 5 | 21 |
Walter Gargano | 33 | 30 | 4 | 3 | 9 | 2 |
Christian Maggio | 33 | 27 | 6 | 6 | 4 | 3 |
Andrea Dossena | 33 | 24 | 13 | 9 | 8 | 2 |
Paolo Cannavaro | 32 | 31 | 3 | 1 | 3 | 3 |
Hugo Campagnaro | 31 | 30 | 2 | 1 | 5 | 2 |
Salvatore Aronica | 31 | 29 | 5 | 2 | 7 | - |
Camilo Zuniga | 31 | 22 | 13 | 9 | 3 | 2 |
Ezequiel Ivan Lavezzi | 30 | 25 | 5 | 5 | 10 | 9 |
Goran Pandev | 30 | 19 | 13 | 11 | 11 | 6 |
Blerim Dzemaili | 28 | 21 | 13 | 7 | 6 | 3 |
Federico Fernandez | 17 | 10 | 27 | 7 | 3 | - |
Miguel Britos | 11 | 9 | 9 | 2 | 4 | 1 |
Eduardo Vargas | 10 | - | 20 | 10 | - | 1 |
Mario Santana | 8 | 4 | 10 | 4 | 3 | - |
Giuseppe Mascara | 7 | 2 | 13 | 5 | 2 | 1 |
Gianluca Grava | 6 | 3 | 12 | 3 | 2 | - |
Ignacio David Fideleff | 3 | 3 | 21 | - | 3 | - |
Cristiano Lucarelli | 3 | - | 6 | 3 | - | - |
Cristian Chavez | 2 | - | 4 | 2 | - | - |
Antonio Rosati | 1 | 1 | 30 | - | - | - |
Massimiliano Ammendola | 1 | - | 6 | 1 | - | - |
Jacopo Dezi | - | - | 4 | - | - | - |
Marco Donadel | - | - | 1 | - | - | - |
Roberto Colombo | - | - | 7 | - | - | - | 526 | 418 | 266 | 108 | 108 | 65 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .