| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Esteban Cambiasso | 37 | 35 | 3 | 2 | 3 | 4 |
Yuto Nagatomo | 36 | 31 | 7 | 5 | 2 | 2 |
Javier Zanetti | 35 | 33 | - | 2 | 1 | 1 |
Lucio | 34 | 34 | - | - | - | 1 |
Julio Cesar | 33 | 33 | - | - | 1 | - |
Giampaolo Pazzini | 33 | 22 | 16 | 11 | 6 | 5 |
Diego Milito | 32 | 29 | 7 | 3 | 12 | 24 |
Walter Samuel | 27 | 27 | 2 | - | 3 | 2 |
Joel Obi | 26 | 11 | 21 | 15 | 7 | - |
Maicon | 24 | 24 | - | - | 1 | 2 |
Ricardo Alvarez | 22 | 15 | 9 | 7 | 11 | 2 |
Wesley Sneijder | 20 | 15 | 5 | 5 | 9 | 4 |
Dejan Stankovic | 20 | 14 | 6 | 6 | 4 | - |
Mauro Zarate | 20 | 10 | 22 | 10 | 6 | 1 |
Diego Forlan | 18 | 14 | 7 | 4 | 11 | 2 |
Andrea Poli | 18 | 9 | 16 | 9 | 7 | - |
Marco Davide Faraoni | 14 | 7 | 12 | 7 | 5 | 1 |
Cristian Chivu | 13 | 13 | 7 | - | 6 | - |
Andrea Ranocchia | 12 | 11 | 15 | 1 | - | 1 |
Thiago Motta | 10 | 10 | 2 | - | - | 3 |
Luca Castellazzi | 7 | 5 | 31 | 2 | - | - |
Fredy Guarin | 5 | 5 | 4 | - | 3 | - |
Philippe Coutinho | 5 | 4 | 4 | 1 | 4 | 1 |
Luca Castaignos | 5 | 1 | 18 | 4 | 1 | 1 |
Jonathan | 4 | 2 | 7 | 2 | 1 | - |
Ivan Cordoba | 4 | 1 | 20 | 3 | - | - |
Sulley Muntari | 4 | 1 | 5 | 3 | - | - |
Angelo Palombo | 3 | 2 | 7 | 1 | 1 | - |
Samuele Longo | 1 | - | 1 | 1 | - | - |
Juan | 1 | - | 2 | 1 | - | - |
Marko Livaja | - | - | 1 | - | - | - |
Luca Caldirola | - | - | 1 | - | - | - |
Alfred Duncan | - | - | 1 | - | - | - |
Matteo Bianchetti | - | - | 1 | - | - | - |
Paulo Orlandoni | - | - | 6 | - | - | - | 523 | 418 | 266 | 105 | 105 | 57 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .