| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Cristian Ledesma | 37 | 36 | 1 | 1 | - | 3 |
Hernanes | 31 | 27 | 6 | 4 | 21 | 8 |
Alvaro Gonzalez | 31 | 23 | 9 | 8 | 4 | 1 |
Federico Marchetti | 30 | 30 | - | - | 1 | - |
Miroslav Klose | 27 | 26 | 1 | 1 | 4 | 12 |
Senad Lulic | 27 | 23 | 5 | 4 | 6 | 4 |
Abdoulay Konko | 26 | 25 | 3 | 1 | 3 | - |
Giuseppe Biava | 26 | 25 | 3 | 1 | 5 | 1 |
Modibo Diakite | 25 | 19 | 15 | 6 | - | 1 |
Andre Dias | 23 | 22 | 2 | 1 | 3 | - |
Stefan Radu | 21 | 21 | - | - | 2 | - |
Matuzalem | 21 | 12 | 10 | 9 | 3 | 1 |
Tommaso Rocchi | 20 | 17 | 13 | 3 | 13 | 5 |
Lionel Scaloni | 19 | 11 | 20 | 8 | 1 | 1 |
Djibril Cisse | 18 | 13 | 6 | 5 | 5 | 1 |
Libor Kozak | 17 | 4 | 22 | 13 | 2 | 4 |
Stefano Mauri | 16 | 14 | 2 | 2 | 7 | 4 |
Lorik Cana | 16 | 9 | 17 | 7 | 4 | 2 |
Christian Brocchi | 15 | 12 | 4 | 3 | 4 | - |
Antonio Candreva | 15 | 10 | 7 | 5 | 5 | 3 |
Javier Garrido | 11 | 10 | 5 | 1 | 4 | - |
Marius Stankevicius | 11 | 9 | 9 | 2 | 2 | - |
Guiseppe Sculli | 11 | 5 | 9 | 6 | 4 | 2 |
Luciano Zauri | 8 | 6 | 11 | 2 | 2 | - |
Emiliano Alfaro | 8 | 1 | 12 | 7 | 2 | - |
Albano Bizzarri | 7 | 7 | 26 | - | - | - |
Antonio Rozzi | 3 | - | 6 | 3 | - | - |
Simone Del Nero | 2 | - | 4 | 2 | - | - |
Juan Carrizo | 2 | - | 9 | 2 | - | - |
Luis Pedro Cavanda | 1 | 1 | 1 | - | 1 | - |
Enrico Zampa | 1 | - | 12 | 1 | - | - |
Alessandro Berardi | - | - | 3 | - | - | - |
Andrea Sbraga | - | - | 5 | - | - | - |
Guglielmo Stendardo | - | - | 3 | - | - | - |
Ayodele Stephen Makinwa | - | - | 2 | - | - | - | 526 | 418 | 263 | 108 | 108 | 53 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .