| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Morgan De Sanctis | 38 | 38 | - | - | - | - |
Marek Hamsik | 36 | 36 | 1 | - | 17 | 11 |
Walter Gargano | 36 | 29 | 7 | 7 | 8 | - |
Edinson Cavani | 35 | 32 | 3 | 3 | 5 | 26 |
Christian Maggio | 33 | 33 | 4 | - | 6 | 4 |
Andrea Dossena | 33 | 31 | 4 | 2 | 17 | 1 |
Paolo Cannavaro | 32 | 31 | 4 | 1 | 2 | 2 |
Michele Pazienza | 31 | 30 | 2 | 1 | 10 | 1 |
Hugo Campagnaro | 31 | 30 | 2 | 1 | - | - |
Ezequiel Ivan Lavezzi | 31 | 29 | 2 | 2 | 6 | 6 |
Hassan Yebda | 28 | 15 | 17 | 13 | 5 | - |
Camilo Zuniga | 27 | 15 | 18 | 12 | 6 | 2 |
Salvatore Aronica | 25 | 19 | 13 | 6 | 1 | - |
Jose Sosa | 23 | 7 | 26 | 16 | 7 | 1 |
Gianluca Grava | 13 | 12 | 7 | 1 | 4 | - |
Giuseppe Mascara | 13 | 4 | 10 | 9 | 1 | 3 |
Fabiano Santacroce | 10 | 10 | 21 | - | 4 | - |
Emilson Cribari | 9 | 6 | 19 | 3 | 1 | - |
Cristiano Lucarelli | 9 | 1 | 16 | 8 | - | 1 |
Nicolao Dumitru | 9 | - | 20 | 9 | - | - |
Victor Ruiz | 6 | 6 | 7 | - | - | - |
Luigi Vitale | 6 | 2 | 11 | 4 | 1 | - |
Raffaele Maiello | 3 | 1 | 4 | 2 | - | - |
Manuele Blasi | 2 | 1 | 8 | 1 | - | - |
Camillo Ciano | - | - | 1 | - | - | - |
Gennaro Iezzo | - | - | 37 | - | - | - |
Erminio Rullo | - | - | 1 | - | - | - |
Matteo Gianello | - | - | 1 | - | - | - | 519 | 418 | 266 | 101 | 101 | 58 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .