| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Alberto Gilardino | 35 | 35 | - | - | 10 | 12 |
Alessandro Gamberini | 35 | 35 | - | - | 1 | 1 |
Manuel Pasqual | 34 | 33 | 1 | 1 | 4 | 1 |
Riccardo Montolivo | 29 | 29 | 1 | - | 4 | 2 |
Marco Donadel | 29 | 26 | 8 | 3 | 7 | 1 |
Mario Santana | 28 | 22 | 9 | 6 | 10 | 4 |
Artur Boruc | 26 | 26 | 9 | - | - | - |
Lorenzo De Silvestri | 26 | 23 | 14 | 3 | 2 | 1 |
Adem Ljajic | 26 | 14 | 21 | 12 | 12 | 3 |
Juan Manuel Vargas | 24 | 19 | 5 | 5 | 9 | 4 |
Alessio Cerci | 24 | 17 | 14 | 7 | 12 | 7 |
Marco Marchionni | 24 | 13 | 18 | 11 | 7 | 1 |
Adrian Mutu | 20 | 18 | 2 | 2 | 6 | 4 |
Cesare Natali | 20 | 16 | 6 | 4 | 3 | - |
Gianluca Comotto | 20 | 16 | 21 | 4 | 2 | - |
Gaetano D'Agostino | 20 | 12 | 17 | 8 | 6 | 5 |
Per Kroldrup | 19 | 17 | 8 | 2 | - | - |
Khouma Babacar | 18 | 3 | 29 | 15 | - | - |
Valon Behrami | 17 | 15 | 2 | 2 | 5 | - |
Sebastian Frey | 11 | 11 | 4 | - | - | - |
Mario Bolatti | 10 | 1 | 16 | 9 | 1 | - |
Michele Camporese | 9 | 7 | 13 | 2 | 1 | 1 |
Cristiano Zanetti | 6 | 4 | 5 | 2 | 2 | - |
Nikola Gulan | 6 | 3 | 4 | 3 | 2 | - |
Felipe | 5 | 2 | 8 | 3 | 1 | - |
Vlada Avramov | 1 | 1 | 6 | - | - | - |
Cristiano Piccini | 1 | - | 1 | 1 | - | - |
Amidu Salifu | 1 | - | 1 | 1 | - | - |
Papa Waigo | 1 | - | 3 | 1 | - | - |
Andrea Seculin | - | - | 3 | - | - | - |
Neto | - | - | 13 | - | - | - | 525 | 418 | 262 | 107 | 107 | 47 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .