| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Samuel Eto'o | 35 | 35 | - | - | 9 | 21 |
Javier Zanetti | 35 | 35 | - | - | 1 | - |
Lucio | 31 | 30 | 1 | 1 | 1 | 1 |
Esteban Cambiasso | 30 | 28 | 3 | 2 | 6 | 7 |
Maicon | 28 | 28 | - | - | 1 | 1 |
Goran Pandev | 27 | 17 | 19 | 10 | 8 | 2 |
Dejan Stankovic | 26 | 22 | 5 | 4 | 10 | 5 |
Julio Cesar | 25 | 25 | 1 | - | 1 | - |
Wesley Sneijder | 25 | 22 | 3 | 3 | 7 | 4 |
Cristian Chivu | 24 | 24 | 3 | - | 6 | 1 |
Diego Milito | 23 | 16 | 9 | 7 | 9 | 5 |
Ivan Cordoba | 22 | 15 | 10 | 7 | 1 | - |
Thiago Motta | 19 | 15 | 5 | 4 | 5 | 4 |
Andrea Ranocchia | 18 | 17 | 4 | 1 | 3 | - |
Giampaolo Pazzini | 16 | 14 | 4 | 2 | 7 | 11 |
Luca Castellazzi | 15 | 13 | 23 | 2 | - | - |
Houssine Kharja | 15 | 10 | 7 | 5 | 4 | 2 |
Jonathan Biabiany | 14 | 9 | 10 | 5 | 9 | - |
Yuto Nagatomo | 13 | 10 | 6 | 3 | 2 | 2 |
Philippe Coutinho | 13 | 8 | 17 | 5 | 3 | 1 |
Davide Santon | 12 | 5 | 14 | 7 | 2 | - |
McDonald Mariga | 11 | 2 | 20 | 9 | - | - |
Walter Samuel | 10 | 8 | 3 | 2 | 2 | - |
Joel Obi | 10 | 2 | 19 | 8 | 2 | - |
Marco Materazzi | 8 | 6 | 31 | 2 | 2 | - |
Sulley Muntari | 8 | 1 | 10 | 7 | 1 | 1 |
Felice Natalino | 2 | 1 | 5 | 1 | 1 | - |
Denis Alibec | 2 | - | 4 | 2 | - | - |
Mancini | 2 | - | 3 | 2 | - | - |
Nwankwo Obiora | 2 | - | 8 | 2 | - | - |
Paulo Orlandoni | - | - | 14 | - | - | - |
Nelson Rivas | - | - | 1 | - | - | - |
Cristiano Biraghi | - | - | 1 | - | - | - |
Simone Benedetti | - | - | 1 | - | - | - |
Marco Davide Faraoni | - | - | 1 | - | - | - | 521 | 418 | 265 | 103 | 103 | 68 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .