| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Christian Abbiati | 35 | 35 | - | - | 1 | - |
Thiago Silva | 33 | 33 | - | - | 2 | 1 |
Robinho | 33 | 26 | 9 | 7 | 9 | 14 |
Gennaro Gattuso | 31 | 28 | 3 | 3 | 13 | 2 |
Clarence Seedorf | 30 | 23 | 11 | 7 | 9 | 4 |
Zlatan Ibrahimovic | 29 | 29 | - | - | 4 | 14 |
Ignazio Abate | 29 | 26 | 6 | 3 | 2 | - |
Alessandro Nesta | 26 | 26 | 1 | - | 2 | - |
Kevin-Prince Boateng | 26 | 18 | 9 | 8 | 8 | 3 |
Alexandre Pato | 25 | 19 | 7 | 6 | 10 | 14 |
Luca Antonini | 22 | 18 | 10 | 4 | 3 | - |
Mathieu Flamini | 22 | 14 | 14 | 8 | 2 | 2 |
Massimo Ambrosini | 18 | 16 | 2 | 2 | 4 | 1 |
Andrea Pirlo | 17 | 12 | 7 | 5 | 1 | 1 |
Antonio Cassano | 17 | 9 | 11 | 8 | 6 | 4 |
Daniele Bonera | 16 | 15 | 10 | 1 | 2 | - |
Gianluca Zambrotta | 15 | 15 | 5 | - | 1 | - |
Mark van Bommel | 14 | 14 | 1 | - | 2 | - |
Mario Yepes | 13 | 11 | 24 | 2 | - | - |
Ronaldinho Gaucho | 11 | 7 | 8 | 4 | 2 | - |
Urby Emanuelson | 8 | 2 | 12 | 6 | - | - |
Massimo Oddo | 7 | 3 | 10 | 4 | - | - |
Alexander Merkel | 6 | 6 | 5 | - | 4 | - |
Filippo Inzaghi | 6 | 1 | 12 | 5 | 2 | 2 |
Sokratis Papastathopoulos | 5 | 3 | 20 | 2 | - | - |
Marek Jankulovski | 5 | 3 | 9 | 2 | 2 | - |
Marco Amelia | 4 | 3 | 31 | 1 | - | - |
Rodney Strasser | 3 | 1 | 8 | 2 | - | 1 |
Marco Borriello | 1 | 1 | - | - | 1 | - |
Didac Vila | 1 | 1 | 2 | - | - | - |
Giacomo Beretta | 1 | - | 2 | 1 | - | - |
Nicola Legrottaglie | 1 | - | 1 | 1 | 1 | - |
Nnamdi Oduamadi | 1 | - | 2 | 1 | - | - |
Bruno Montelongo | - | - | 3 | - | - | - |
Flavio Roma | - | - | 7 | - | - | - |
Simone Calvano | - | - | 2 | - | - | - | 511 | 418 | 264 | 93 | 93 | 63 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .