| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Leonardo Bonucci | 35 | 33 | 4 | 2 | - | - |
Alessandro Del Piero | 35 | 19 | 17 | 16 | 11 | 8 |
Alberto Aquilani | 34 | 32 | 3 | 2 | 11 | 2 |
Claudio Marchisio | 33 | 33 | 1 | - | 6 | 4 |
Milos Krasic | 33 | 33 | - | - | 12 | 6 |
Giorgio Chiellini | 32 | 32 | - | - | - | 2 |
Simone Pepe | 32 | 23 | 10 | 9 | 9 | 4 |
Felipo Melo | 30 | 29 | 1 | 1 | 6 | 1 |
Marco Storari | 24 | 23 | 15 | 1 | - | - |
Marco Motta | 22 | 19 | 10 | 3 | 9 | - |
Fabio Grosso | 20 | 18 | 3 | 2 | 4 | - |
Vincenzo Iaquinta | 20 | 9 | 11 | 11 | 6 | 5 |
Fabio Quagliarella | 18 | 18 | 1 | - | 7 | 9 |
Frederik Sorensen | 18 | 13 | 14 | 5 | 3 | - |
Mohamed Sissoko | 18 | 4 | 19 | 14 | 1 | - |
Gianluigi Buffon | 16 | 16 | - | - | - | - |
Alessandro Matri | 15 | 15 | 1 | - | 7 | 9 |
Andrea Barzagli | 15 | 14 | 2 | 1 | - | - |
Luca Toni | 15 | 5 | 10 | 10 | 3 | 2 |
Jorge Martinez | 14 | 6 | 15 | 8 | 5 | - |
Zdenek Grygera | 13 | 9 | 14 | 4 | 2 | - |
Armand Traore | 11 | 7 | 14 | 4 | 5 | - |
Amauri | 10 | 5 | 6 | 5 | 2 | - |
Hasan Salihamidzic | 10 | 1 | 22 | 9 | - | - |
Paolo De Ceglie | 6 | 6 | 2 | - | 2 | - |
Nicola Legrottaglie | 5 | 2 | 14 | 3 | - | 1 |
David Lanzafame | 3 | - | 9 | 3 | - | - |
Manuel Giandonato | 2 | 2 | 9 | - | 1 | - |
Niccolo Giannetti | 1 | 1 | 4 | - | 1 | - |
Leandro Rinaudo | 1 | 1 | 2 | - | 1 | - |
Vincenzo Camilleri | 1 | 1 | 3 | - | - | - |
Alberto Libertazzi | 1 | - | 3 | 1 | - | - |
Marco Constantino | - | - | 5 | - | - | - |
Filippo Boniperti | - | - | 3 | - | - | - |
Vittorio Ferrero | - | - | 2 | - | - | - |
Alex Manninger | - | - | 19 | - | - | - |
Matteo Liviero | - | - | 1 | - | - | - |
Marcel Buchel | - | - | 3 | - | - | - | 543 | 429 | 272 | 114 | 114 | 53 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .