| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Fernando Muslera | 36 | 36 | - | - | - | - |
Hernanes | 36 | 35 | 2 | 1 | 18 | 11 |
Giuseppe Biava | 35 | 35 | - | - | 6 | 3 |
Mauro Zarate | 35 | 28 | 8 | 7 | 16 | 9 |
Stephen Lichtsteiner | 34 | 33 | 2 | 1 | 3 | - |
Cristian Ledesma | 34 | 30 | 5 | 4 | 2 | 1 |
Andre Dias | 33 | 33 | - | - | - | 2 |
Christian Brocchi | 31 | 25 | 7 | 6 | 6 | - |
Stefano Mauri | 29 | 26 | 5 | 3 | 8 | 6 |
Sergio Floccari | 28 | 25 | 7 | 3 | 12 | 8 |
Stefan Radu | 26 | 26 | - | - | 1 | - |
Matuzalem | 22 | 18 | 8 | 4 | 3 | - |
Marco Bresciano | 20 | 7 | 23 | 13 | 4 | - |
Libor Kozak | 19 | 6 | 23 | 13 | - | 6 |
Alvaro Gonzalez | 17 | 8 | 19 | 9 | 5 | 1 |
Tommaso Rocchi | 17 | 6 | 17 | 11 | 5 | 3 |
Guglielmo Stendardo | 14 | 6 | 19 | 8 | 1 | - |
Guiseppe Sculli | 13 | 11 | 5 | 2 | 4 | 2 |
Javier Garrido | 10 | 8 | 12 | 2 | 2 | - |
Lionel Scaloni | 10 | 5 | 18 | 5 | 4 | - |
Pasquale Foggia | 9 | 2 | 19 | 7 | 2 | - |
Modibo Diakite | 8 | 4 | 10 | 4 | 1 | - |
Luis Pedro Cavanda | 3 | 2 | 10 | 1 | 1 | - |
Tommaso Berni | 2 | 2 | 36 | - | - | - |
Simone Del Nero | 2 | 1 | 7 | 1 | 1 | - |
Alessandro Berardi | - | - | 1 | - | - | - |
Albano Bizzarri | - | - | 1 | - | - | - |
Mourad Meghni | - | - | 1 | - | - | - |
Tommaso Ceccarelli | - | - | 1 | - | - | - | 523 | 418 | 266 | 105 | 105 | 52 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .