| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Robert Green | 37 | 37 | - | - | - | - |
Carlton Cole | 35 | 21 | 15 | 14 | 7 | 5 |
Frederic Piquionne | 34 | 26 | 10 | 8 | 13 | 6 |
Scott Parker | 32 | 30 | 2 | 2 | 3 | 5 |
Matthew Upson | 30 | 30 | 1 | - | 5 | - |
Mark Noble | 26 | 25 | 1 | 1 | 4 | 4 |
Daniel Gabbidon | 26 | 24 | 7 | 2 | 1 | - |
Victor Obinna | 25 | 17 | 11 | 8 | 8 | 3 |
Lars Jacobsen | 24 | 22 | 3 | 2 | 2 | - |
Luis Boa Morte | 22 | 19 | 12 | 3 | 11 | - |
James Tomkins | 19 | 18 | 14 | 1 | 2 | 1 |
Manuel Da Costa | 16 | 14 | 5 | 2 | 1 | 1 |
Wayne Bridge | 15 | 15 | - | - | 1 | - |
Pablo Barrera | 14 | 6 | 17 | 8 | 4 | - |
Jonathan Spector | 13 | 9 | 14 | 4 | 2 | 1 |
Radoslav Kovac | 13 | 7 | 20 | 6 | 2 | - |
Demba Ba | 12 | 10 | 3 | 2 | 2 | 7 |
Thomas Hitzlsperger | 11 | 11 | 1 | - | - | 2 |
Herita Ilunga | 11 | 10 | 4 | 1 | 2 | - |
Freddie Sears | 11 | 9 | 7 | 2 | 4 | 1 |
Kieron Dyer | 11 | 8 | 3 | 3 | 7 | - |
Julian Faubert | 9 | 7 | 10 | 2 | 1 | - |
Robbie Keane | 9 | 5 | 4 | 4 | 3 | 2 |
Zavon Hines | 9 | 4 | 12 | 5 | 2 | - |
Tal Ben Haim | 8 | 8 | 2 | - | 1 | - |
Valon Behrami | 8 | 7 | 2 | 1 | 4 | 2 |
Gary O'Neil | 8 | 7 | 2 | 1 | 3 | - |
Winston Reid | 7 | 3 | 19 | 4 | - | - |
Junior Stanislas | 6 | 4 | 5 | 2 | 2 | 1 |
Benni McCarthy | 6 | - | 15 | 6 | - | - |
Jack Collison | 3 | 2 | 1 | 1 | 1 | - |
Jordan Spence | 2 | 2 | 1 | - | - | - |
Frank Nouble | 2 | - | 4 | 2 | - | - |
Ruud Boffin | 1 | 1 | 21 | - | - | - |
Alessandro Diamanti | 1 | - | 1 | 1 | - | - |
Marek Stech | - | - | 15 | - | - | - |
Jake Larkins | - | - | 1 | - | - | - |
Dylan Tombides | - | - | 1 | - | - | - | 516 | 418 | 266 | 98 | 98 | 41 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .