| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Samir Handanovic | 37 | 37 | - | - | - | - |
Antonio Di Natale | 35 | 33 | 2 | 2 | 4 | 29 |
Gokhan Inler | 33 | 32 | 1 | 1 | 6 | - |
Aleksander Lukovic | 33 | 31 | 4 | 2 | 3 | - |
Simone Pepe | 32 | 25 | 8 | 7 | 16 | 7 |
Alexis Sanchez | 32 | 25 | 7 | 7 | 8 | 5 |
Antonio Floro Flores | 32 | 25 | 9 | 7 | 13 | 9 |
Cristian Zapata | 30 | 30 | 4 | - | 2 | - |
Mauricio Isla | 30 | 27 | 3 | 3 | 7 | 1 |
Paolo Sammarco | 27 | 17 | 14 | 10 | 13 | - |
Andrea Coda | 26 | 24 | 4 | 2 | 1 | - |
Kwadwo Asamoah | 25 | 24 | 1 | 1 | 3 | 1 |
Giovanni Pasquale | 22 | 19 | 7 | 3 | 6 | - |
Gaetano D'Agostino | 20 | 18 | 2 | 2 | 7 | 1 |
Francesco Lodi | 19 | 4 | 28 | 15 | 4 | 1 |
Bernardo Corradi | 19 | 2 | 30 | 17 | 1 | - |
Dusan Basta | 16 | 14 | 3 | 2 | 2 | - |
Muarizio Domizzi | 13 | 13 | 10 | - | 2 | - |
Damiano Ferronetti | 12 | 8 | 7 | 4 | 4 | - |
Juan Cuadrado | 11 | 4 | 20 | 7 | 1 | - |
Emmanuel Agyemang-Badu | 5 | - | 14 | 5 | 1 | - |
Jamie Romero | 4 | 1 | 3 | 3 | 1 | - |
Alexandre Geijo | 4 | - | 9 | 4 | - | - |
Felipe | 3 | 3 | 10 | - | 2 | - |
Guilherme Siqueira | 3 | - | 6 | 3 | - | - |
Rafael Romo | 1 | 1 | 3 | - | - | - |
Niki Zimling | 1 | 1 | 8 | - | 1 | - |
Christian Obodo | 1 | - | 2 | 1 | - | - |
Emanuele Belardi | - | - | 33 | - | - | - |
Ritchie Kitoko | - | - | 1 | - | - | - |
Raffaele De Martino | - | - | 1 | - | - | - |
Ricardo Chara | - | - | 4 | - | - | - |
Kelvin Matute | - | - | 1 | - | - | - |
Piermario Morosini | - | - | 2 | - | - | - |
Alin Bucuroiu | - | - | 1 | - | - | - | 526 | 418 | 262 | 108 | 108 | 54 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .