| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Sebastian Frey | 36 | 36 | 1 | - | - | - |
Riccardo Montolivo | 36 | 33 | 3 | 3 | 3 | 2 |
Alberto Gilardino | 36 | 32 | 4 | 4 | 5 | 14 |
Juan Manuel Vargas | 29 | 27 | 2 | 2 | 6 | 5 |
Stevan Jovetic | 29 | 26 | 5 | 3 | 6 | 6 |
Marco Marchionni | 28 | 23 | 6 | 5 | 12 | 7 |
Marco Donadel | 28 | 20 | 14 | 8 | 8 | - |
Gianluca Comotto | 26 | 22 | 9 | 4 | 7 | - |
Mario Santana | 26 | 21 | 6 | 5 | 12 | 3 |
Lorenzo De Silvestri | 26 | 17 | 16 | 9 | 2 | 1 |
Per Kroldrup | 25 | 24 | 5 | 1 | - | 2 |
Massimo Gobbi | 25 | 19 | 14 | 6 | 3 | - |
Cristiano Zanetti | 23 | 16 | 10 | 7 | 8 | - |
Manuel Pasqual | 21 | 18 | 11 | 3 | 9 | - |
Felipe | 18 | 16 | 2 | 2 | 4 | - |
Alessandro Gamberini | 18 | 16 | 2 | 2 | 3 | - |
Cesare Natali | 17 | 14 | 14 | 3 | 4 | - |
Martin Jorgensen | 13 | 2 | 15 | 11 | 1 | - |
Mario Bolatti | 12 | 9 | 10 | 3 | 6 | - |
Dario Dainelli | 11 | 11 | 1 | - | 1 | - |
Adrian Mutu | 11 | 9 | 4 | 2 | 5 | 4 |
Keirrison | 10 | 2 | 14 | 8 | 2 | 2 |
Adem Ljajic | 9 | 3 | 13 | 6 | 2 | - |
Jose Ignacio Castillo | 6 | - | 10 | 6 | - | 1 |
Khouma Babacar | 4 | - | 13 | 4 | - | 1 |
Vlada Avramov | 2 | 2 | 31 | - | - | - |
Federico Carraro | 1 | - | 9 | 1 | - | - |
Daniel Kofi Agyei | 1 | - | 4 | 1 | - | - |
Savio Nsereko | - | - | 1 | - | - | - |
Zdravko Kuzmanovic | - | - | 1 | - | - | - |
Andrea Seculin | - | - | 5 | - | - | - |
Federico Masi | - | - | 2 | - | - | - |
Ramzi Aya | - | - | 2 | - | - | - |
Francesco Di Tacchio | - | - | 1 | - | - | - | 527 | 418 | 260 | 109 | 109 | 48 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .