| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Ronaldinho Gaucho | 36 | 34 | 2 | 2 | 11 | 12 |
Andrea Pirlo | 34 | 33 | 1 | 1 | 3 | - |
Thiago Silva | 32 | 32 | 1 | - | 1 | 1 |
Massimo Ambrosini | 30 | 26 | 5 | 4 | 5 | 1 |
Marco Borriello | 29 | 27 | 2 | 2 | 13 | 14 |
Ignazio Abate | 28 | 21 | 12 | 7 | 4 | - |
Clarence Seedorf | 27 | 23 | 6 | 4 | 7 | 3 |
Gianluca Zambrotta | 24 | 19 | 9 | 5 | 4 | - |
Mathieu Flamini | 24 | 14 | 15 | 10 | 7 | - |
Klass - Jan Huntelaar | 24 | 11 | 24 | 13 | 8 | 7 |
Filippo Inzaghi | 24 | 4 | 32 | 20 | 3 | 2 |
Dida | 23 | 23 | 13 | - | 2 | - |
Alexandre Pato | 23 | 20 | 3 | 3 | 5 | 12 |
Alessandro Nesta | 22 | 22 | 1 | - | 2 | 3 |
Gennaro Gattuso | 22 | 20 | 8 | 2 | 11 | - |
Giuseppe Favalli | 16 | 15 | 18 | 1 | 2 | - |
Massimo Oddo | 15 | 10 | 8 | 5 | 1 | - |
Luca Antonelli | 13 | 12 | 3 | 1 | 2 | - |
Marek Jankulovski | 13 | 5 | 22 | 8 | 2 | - |
David Beckham | 11 | 7 | 5 | 4 | 1 | - |
Christian Abbiati | 10 | 8 | 9 | 2 | - | - |
Luca Antonini | 9 | 8 | 4 | 1 | 3 | 1 |
Marco Storari | 7 | 7 | 6 | - | - | - |
Daniele Bonera | 7 | 6 | 4 | 1 | 3 | - |
Mancini | 7 | 3 | 7 | 4 | 2 | - |
Kakha Kaladze | 6 | 5 | 17 | 1 | - | - |
Chedric Seedorf | 2 | 2 | - | - | 3 | 2 |
Marco Simone | 1 | 1 | 1 | - | - | 1 |
Salim Cisse | 1 | - | - | 1 | - | - |
Andrea De Vito | 1 | - | 1 | 1 | - | - |
Gianmarco Zigoni | 1 | - | 2 | 1 | - | - |
Rodney Strasser | 1 | - | 4 | 1 | - | - |
Flavio Roma | - | - | 10 | - | - | - |
Oguchi Onyewu | - | - | 5 | - | - | - |
Davide Di Gennaro | - | - | 2 | - | - | - |
Simone Verdi | - | - | 1 | - | - | - |
Michaelangelo Albertazzi | - | - | 1 | - | - | - | 523 | 418 | 264 | 105 | 105 | 59 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .